This review discusses methods widely used in pharmaceutical and clinical practice for the identification and assay of the thyrostatic agents imidazoline-2-thione and uracil-2-thiones. Sample preparation stages (solid-phase and liquid extraction from biological materials) are discussed, along with chemical modification of drug molecules. A scheme for a hypothetical model of the inhibitory action of thyrostatic agents on thyroid hormone biosynthesis is presented. The analytical characteristics of individual methods for assaying thyrostatic agents discussed in this review can be used in manufacturing at the quality control stage.

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