HPLC determination of antithyroid drugs

Chernov’yants, M. S.; Dolinkin, A. O.; Khokhlov, E. V.

doi:10.1134/s1061934809080103

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…These methods do not involve the identification of degradation products and are not suitable for LC-MS studies. Other reported methods include the study of the effect of temperature on stability of extemporaneously prepared oral suspensions by HPLC 8 , bioanalytical HPLC methods, for estimation in plasma, serum, 9,10 urine 11 and metabolism studies by LC-MS/MS 12 .…”

Section: Introductionmentioning

confidence: 99%

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2021

IJPSR

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A simple, precise, accurate, sensitive and robust stabilityindicating HPLC method for simultaneous estimation of propylthiouracil and its impurity thiourea has been proposed. The separation was achieved on a C 18 column (4.6 mm × 150 mm, particle size 5.0 μm) maintained at 45 ºC with a mobile phase composed of water: methanol: acetonitrile (50:35:15 v/v/v) with 0.1% acetic acid and detection wavelength was 241 nm. In statistical analysis, the linear response in the range of 30 -300 μg/ml for propylthiouracil and 0.3 -30 μg/ml for thiourea with a correlation coefficient greater than 0.99 was obtained. In forced degradation studies, PTU was found to degrade under basic hydrolysis, oxidative and photo stress while found resistant to acid/neutral hydrolysis and thermal degradation. The probable structures of six major degradants generated under stress conditions were identified by LC-MS studies and the most likely degradation pathway was proposed from mass spectral data. The information presented herein could be very useful for the impurity profiling of drugs as well as can be employed to check the drug product quality during stability studies.

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Section: Introductionmentioning

confidence: 99%

Untitled

2021

IJPSR

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“…Owing to the fact that reliable analytical methods in the area of clinical research are needed to determine drugs in biological media, study of these matrices is crucial. In order to control the treatment compliance of patients and risk of intoxication, the study of potential pharmacokinetic interactions of a specific drug with other medications as well as analytical investigations and quantification determination of drugs in biological samples are important (Chernov'yants, Dolinkin, & Khokhlov, ). Four essential steps are vital for analysis of biological matrices: extraction of favourable compound from biological samples; removal of interfering agents; detection; and handling of data.…”

Section: Introductionmentioning

confidence: 99%

Employment of modified Fe₃O₄ nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

Naghibi

Sahebi

2017

Biomedical Chromatography

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Cefexime is a useful antibiotic that can be prescribed to treat bacterial infections. Nanoparticles have been widely marketed as a universal solution among scientists. Many studies have been performed to modify nanoparticles to make them functional as extraction and pre-concentration agents and drug carriers. Temperature-sensitive polymers belong to a group of substances that undergo a major change in their physical features in response to temperature. Recently developed polymers can be used in many different areas, including modification of nanoparticles. In order to modify this nanoparticle, grafting copolymerization of Fe O nanoparticles was performed using poly (N-vinylcaprolactam) and 3-allyloxy-1,2-propanediol. The optimum conditions for pre-concentration of cefexime were studied. Under these optimum conditions, extraction recovery of biological samples in the range of 71-89% was obtained. The limit of detection and precision of proposed method were 4.5 × 10 μg mL and <4.11% (relative standard deviation), respectively. Based on the results from analysis of cefexime, in biological samples using the proposed method, the ability of this method to extract and pre-concentrate cefexime was confirmed. Also, satisfactory results from an in vitro study on drug release in simulated intestine media were obtained.

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Determination of low molecular thiols and protein sulfhydryl groups using heterocyclic disulfides

2022

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HPLC determination of antithyroid drugs

Cited by 6 publications

References 13 publications

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Employment of modified Fe₃O₄ nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

Determination of low molecular thiols and protein sulfhydryl groups using heterocyclic disulfides

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HPLC determination of antithyroid drugs

Cited by 6 publications

References 13 publications

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Employment of modified Fe3O4 nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

Determination of low molecular thiols and protein sulfhydryl groups using heterocyclic disulfides

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Employment of modified Fe₃O₄ nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples