Abstract:A simple, precise, accurate, sensitive and robust stabilityindicating HPLC method for simultaneous estimation of propylthiouracil and its impurity thiourea has been proposed. The separation was achieved on a C 18 column (4.6 mm × 150 mm, particle size 5.0 μm) maintained at 45 ºC with a mobile phase composed of water: methanol: acetonitrile (50:35:15 v/v/v) with 0.1% acetic acid and detection wavelength was 241 nm. In statistical analysis, the linear response in the range of 30 -300 μg/ml for propylthiouracil a… Show more
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