Electrophoretic determination of 1-methyl-2-mercaptoimidazole in the pharmaceutical preparation mercazolyl

Chernov’yants, M. S.; Khokhlov, E. V.; Lykova, E. O.; Dolinkin, A. O.

doi:10.1134/s1061934807030124

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…ethimazole, also called as thiamazole, is an antithyroid agent, has gained a distinct value in the medical world because it is very effective in hyperthyroidism [1][2][3][4]. The literature survey for methimazole reveals several analytical methods such as spectrophotometry [5][6][7], Pharmacopoeia method [8], voltammetry [9][10][11], HPLC [12][13][14], electrophoresis [15]. Spectrophotometric methods are commonly used in pharmaceutical analysis due to being simple, cheap and fast methods compared to other methods.…”

Section: Introductionmentioning

confidence: 99%

Determination of Methimazole in Tablets Using Spectrophotometric Methods

Dermiş

Beyaztaş

Ertekin

et al. 2019

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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This study describes the spectrophotometric quantification of methimazole in tablets using zero-order absorption spectrophotometry and first derivative spectrophotometry methods. In preliminary experiments, linearity range was found between 2.0-24.0 µg/mL in zero-order spectrophotometry and first-order derivative spectrophotometry. Calibration curves were obtained by measurements of the zero-order absorbances and their first derivative values at 260.0 and 269.0 nm for the zero-order spectrophotometry and first derivative spectrophotometry, respectively. The recovery and relative standard deviations were calculated as 103.3 % and 2.18 % for UV absorption spectrophotometry and 98.0% and 0.64% for first derivative spectrophotometry, respectively. The proposed techniques were used for the analysis of tablets preparations. The methods proposed in this study were verified by analyzing validation test samples containing methimazole. Determination results showed that the applied methods were found to suitable for the quantitation of the related drug.

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