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International audienceIn this article, we present a few lessons we learnt in the establishment of the Sciences Po médialab. As an interdisciplinary laboratory associating social scientists, code developers and information designers, the médialab is not one of a kind. In the last years, several of such initiatives have been established around the world to harness the potential of digital technologies for the study of collective life. If we narrate this particular story, it is because, having lived it from the inside, we can provide an intimate account of the surprises and displacements of digital research. Founding the médialab in 2009, we knew that we were leaving the reassuring traditions of social sciences to venture in the unexplored territory of digital inscriptions. What we couldn't foresee was how much such encounter would change our research. Buying into gospel of Big Data, we imagined that the main novelty of digital research came from handling larger amounts of data. We soon realized that the interest of digital inscriptions comes instead from their proliferating diversity. Such diversity encouraged us to reshape our professional alliances, research practices and theoretical perspectives. It also led us to overcome several of the oppositions that used to characterize social sciences (qualitative/quantitative, situation/aggregation, micro/ macro, local/global) and to move in the direction of a more continuous sociology

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Over and above established criteria, the present study highlighted the importance of general health and nutritional status during treatment.

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This chapter is about the politics of interdisciplinarity. Not in the sense of the research politics fostering collaboration across disciplines, but in the stronger sense of transcending disciplinary boundaries to make significant political contributions. In short: it is about making research public. To address this question, this chapter introduces (through a concrete example in climate debate research) an original research format, that we call data-sprinting.« It is controversies of this kind, the hardest controversies to disentangle, that the public is called in to judge. Where the facts are most obscure, where precedents are lacking, where novelty and confusion pervade everything, the public in all its unfitness is compelled to make its most important decisions » (Lippmann, 1925, p. 121). What's in a data-sprintData-sprints are intensive research and coding workshops where participants coming from different academic and non-academic background convene physically to work together on a set of data and research questions.Data-sprints have their roots in a series of organizational innovation introduced in the field of open-source development at the turn of the century (as a reaction to the previsous 'waterfall approach' inherited from the engineering management - Raymond, 2001). Faced with such radical uncertainty about how their project will develop and who will join them, open-source developers invented a form of coding event called "barcamps" or "hackathons" (or hacking marathons). Such format consists of short events in which a group of developers and designers meet to work intensively and expeditiously on some digital object.

The secretion of tumour necrosis factor-α (TNFα), interleukin-1α (IL-α) and interleukin-6 (IL-6) by a human astrocytoma cell fine was studied 1 h, 3 h, 6 h and 24 h after infection with tachyzoites from three Toxoplasma gondii strains (virulent, RH; cystogentc, 76K and Prugniaud strains). The astrocytoma cell fine constitutively secreted TNFα and IL-6, but no IL-1α. A positive control was obtained by stimulation with phorbol esters inducing a significant increase (p < 0.05) in TNFα and IL- 6 secretion but not in IL-1α, while lipopolysaccharide (alone and after priming), interferon gamma, ionophore A 23187 and sera positive to T. gondii did not induce any increase in cytokine levels. None of the tachyzoites, whatever their virulence, induced a significant increase in cytokine production at any time in the study. Tachyzoites did not inhibit the secretion induced by phorbol esters.