Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and François Baclesse Cancer Care Center between 1998 and 2008

Cuny, F.; Meunier, A.; Heutte, Natacha; Rame, Jean-Pierre; Raucourt, D. De; Babin, E.; Blanchard, D.

doi:10.1016/j.anorl.2015.03.007

Cited by 9 publications

(14 citation statements)

References 20 publications

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“…Although this factor was not significant in multivariate analysis for local failure in their study, it remained an independent predictor of ultimate local failure ( p = .023). This finding was further supported by Cuny et al who reported lower recurrence‐free survival for patients with WHO performance status >1. We identified WHO performance status >0 as an independent predictive factor for recurrence in general and for local recurrence in particular.…”

Section: Discussionsupporting

confidence: 69%

Predictive factors and treatment outcome of laryngeal carcinoma recurrence

et al. 2016

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Section: Discussionsupporting

confidence: 69%

Predictive factors and treatment outcome of laryngeal carcinoma recurrence

et al. 2016

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“…Last, noncancer and treatment-related deaths were higher in the concomitant arm. 9 Although there is no consensus in the literature 8,[12][13][14][15][16][17][18][19] about the optimal definition of OFPF, the definition used in the current study covers, in our opinion, all the relevant issues involved in functional outcomes of these patients. Furthermore, the data on predictive factors for OFPF are scarce and frequently conflicting.…”

Section: Discussionmentioning

confidence: 99%

Organ Function Preservation Failure after (Chemo)Radiotherapy in Head and Neck Cancer: A Retrospective Cohort Analysis

Heukelom

Navran

Gouw

et al. 2019

Otolaryngol.--head neck surg.

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Objective The aim of the current study was to determine the incidence of organ function preservation failure (OFPF) in patients with head and neck squamous cell carcinoma (HNSCC) treated by (chemo)radiotherapy and to identify its risk factors. Study Design Retrospective cohort analysis. Setting Tertiary cancer care center. Subjects and Methods A single-center retrospective cohort analysis was done (n = 703) in which OFPF after (chemo)radiotherapy was assessed. OFPF was defined as local failure or pure functional failure in the absence of local failure because of major surgical intervention (total laryngectomy, commando resection, permanent tracheostomy) or feeding tube dependence >2 years. Results OFPF occurred in 153 patients (21.8%). Reasons for OFPF were local failure in 103 patients (14.6%) and functional failure in 50 patients (7.2%). Evidence of functional failure included need for total laryngectomy (n = 9, 1.3%), commando resection (n = 2, 0.3%), permanent tracheostomy (n = 16, 2.3%), and/or long-term feeding tube for functional reasons (n = 23, 3.3%). In a Cox proportional hazards model, OFPF was worse for patients with T4 tumors (hazard ratio [HR] <0.5 and P < .001 for all other stages), for laryngeal vs oropharyngeal cancer (HR, 1.83; 95% confidence interval [CI], 1.20-2.79, P = .005, hypopharyngeal not significant), and for smokers (HR, 1.68; 95% CI, 1.10-2.56, P = .015). Exploratory multivariate analysis by tumor site showed that T4 tumor and pretreatment tracheostomy were the strongest predictive factors for OFPF in laryngeal and hypopharyngeal carcinoma while T4 tumor and smoking were predictive for poor OFPF in oropharyngeal carcinoma. Conclusion This work shows a detrimental effect of smoking on functional outcomes after (chemo-)radiotherapy for HNSCC. Moreover, T4 tumor, laryngeal subsite, and pretreatment tracheostomy are strong predictors of OFPF.

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“…4,18e22 Additional confounding factors that may be recognized in the literature are the anatomical localization of the tumor (larynx, hypopharynx, oropharynx) and resectability of the tumor. 23 With TNM staging being revised in 2002 so as to restage former T2 tumors with involvement of the paraglottic space as T3, this became an additional parameter of heterogeneity among studies. Unfortunately, few of the studies which were running at the time, appear to have restaged their populations to meet the 6th edition of the International Union Against Cancer (UICC) TNM staging criteria and this has been proved to be a major exclusion criterion for this study.…”

Section: Populationmentioning

confidence: 99%

Systematic review on T3 laryngeal squamous cell carcinoma; still far from a consensus on the optimal organ preserving treatment

Riga

Chelis

Danielides

et al. 2017

European Journal of Surgical Oncology (EJSO)

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Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and François Baclesse Cancer Care Center between 1998 and 2008

Abstract: Over and above established criteria, the present study highlighted the importance of general health and nutritional status during treatment.

Cited by 9 publications

References 20 publications

Predictive factors and treatment outcome of laryngeal carcinoma recurrence

Predictive factors and treatment outcome of laryngeal carcinoma recurrence

Organ Function Preservation Failure after (Chemo)Radiotherapy in Head and Neck Cancer: A Retrospective Cohort Analysis

Systematic review on T3 laryngeal squamous cell carcinoma; still far from a consensus on the optimal organ preserving treatment

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