The respective degrees of morbidity induced by 6 strains each of Nocardia brasiliensis, N. asteroides and N. caviae were investigated by the method of inoculation in the plantar pad of the white mouse, using a suspension of these nocardiae at a concentration of 10 rag/0.1 ml., and inspecting the animals one month, two months and three months following inoculation.All of the strains of N. brasiliensis produced attack greater and more consistent than that of the other species, N. caviae and 2(. asteroides showing patterns of attack similar to each other, hut substantially lower than those obtained with N. brasiliensis. The 6 strains of N. brasiliensis showed different rates of infection at different times of observation, but it was constantly high for all of them; on the other hand, the infectiousness of the different strains of N. caviae and N. asteroides was low, and there were no substantial differences between them, To sum up, these results with 6 strains of each species confirm those that were published in 1973 which dealt with only one strain of each species.In 1967 Gonz/dez-Ochoa and Hojyo-Tomoka found a good experimental model for the reproduction of the mycetoma caused by N. brasiliensis, by inoculating the actinomycete in the plantar pad of the white mouse. In this way they induced in the animal a mycetoma similar to that in the human; that is, a fistulous tumour with granules without spontaneous tendency to heal. astewides was as follows: we isolated strains 4437 and 4424 from a mycetoma and a nocardiosis of the lung, respectively; strains 4407, 4427, 4410 and 4430 were sent to us, in the order mentioned, from the Medical Faculty of Sao Paulo under number 18, 255 Med Mycol Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/20/14 For personal use only.

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Summary Primary pulmonary histoplasmosis in Mexico is distributed throughout the country, although the agent: Histoplasma capsulation principally is restricted to caves, abandoned mines and houses, where bat guano is found. This agent has caused several epidemic outbreaks, characterized by clinical severity and elevated lethality. Due to these characteristics, histoplasmosis has become a great obstacle for the exploration of old mines in many regions and, therefore, has been a serious deterrent to mining development. In this work we make reference to an epidemic outbreak which occurred in a group of 15 workers employed to clean the Neptuno tunnel of an abandoned mine, whose entrance was occluded by a fall. All the members of the group became ill and 6 died, constituting the worst epidemic outbreak of histoplasmosis described in Mexico. Zusammenfassung Die „Histoplasmosis Pulmonar Primaria” findet man in ganz Mexiko, wenngleich auch beschränkt auf Höhlen, verlassene Häuser und Minen, in denen sich größere Mengen von Fledermausexkrementen angesammelt haben. So entstehen zahlreiche epidemische Krankheitsherde, gekennzeichnet durch die Schwere des klinischen Bildes und durch den hohen Prozentsatz an Todesfällen des betroff enen Personenkreises. Infolge dieser charakteristischen Tatsache, daß man Histoplasma capsulatum praktisch nur in Höhlen und verlassenen Minen vorfindet, hat sich die Histoplasmose als ein großes Hindernis bei der Erkundung alter Minen erwiesen, und zwar in einer Region, welche zahlreiche derartige Minen aufzuweisen hat, und wodurch die Minenaufschließung in dieser Gegend sehr erschwert wird. In diesem Artikel wird auf eine Histoplasmose‐Epidemie Bezug genommen, von der eine 15köpfige Arbeitergruppe befallen wurde. Diese war zur Reinigung des Tunnel „Neptune” eingesetzt worden, dessen Eingang durch einen Erdrutsch verschüttet war. Im Laufe dieser Arbeit erkrankten sämtliche Arbeiter, und 6 dieser Personen starben.

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