“…3,4'-dione], a chemically neutral systemic antifungal antibiotic, is commonly used in the treatment of dermatophyte infections in humans (1,2). As a result of its low aqueous solubility (-15 mgfiiter at 37"), the drug is slowly, erratically, and incompletely absorbed from the GI tract of humans (3)(4)(5)(6). Although oral administration of the micronized form of griseofulvin alone (7)(8)(9), with meals high in fat content (7,9), or as a 1:9 (w/w) drug-polyethylene glycol 6000 solid dispersion (10) considerably enhances the bioavailability of the drug, its absorption from commercial tablet (11) and methylcellulose suspension (12) dosage forms is poor and quite variable.…”