New Schemes in the Treatment of Dermatophytoses with Griseofulvin

Bioavailability of Micronized Griseofulvin from Corn Oil‐in‐Water Emulsion, Aqueous Suspension, and Commercial Tablet Dosage Forms in Humans

“…3,4'-dione], a chemically neutral systemic antifungal antibiotic, is commonly used in the treatment of dermatophyte infections in humans (1,2). As a result of its low aqueous solubility (-15 mgfiiter at 37"), the drug is slowly, erratically, and incompletely absorbed from the GI tract of humans (3)(4)(5)(6). Although oral administration of the micronized form of griseofulvin alone (7)(8)(9), with meals high in fat content (7,9), or as a 1:9 (w/w) drug-polyethylene glycol 6000 solid dispersion (10) considerably enhances the bioavailability of the drug, its absorption from commercial tablet (11) and methylcellulose suspension (12) dosage forms is poor and quite variable.…”

An evaluation of intermittent therapies used to treat onychomycosis and other dermatomycoses with the oral antifungal agents

“…Although griseofulvin has been used as intermittent therapy 13–26 in tinea capitis, the preferred regimen is the continuous mode. 10–11 In one study, fluorescent Microsporum tinea capitis was treated with griseofulvin plus benzoic and salicylic acid ointment.…”

“…Itraconazole: an alternative regimen is continuous therapy 5 mg/kg/day × 2–4 weeks. 10–69 The number of pulses required for tinea capitis is in part dependent upon the baseline severity of tinea capitis and the causative organism. Terbinafine: the dosage regimen for: weight < 20 kg, &frac14 tablet/day; 20–40 kg, ½ tablet/day; and > 40 kg, 1 tablet (250 mg)/day.…”

The new oral antifungal agents for onychomycosis of the toenails

“…Reports partially or completely excluded from the meta-analysis can be found in Refs. [41,[44][45][46][48][49][50][51][52][53][54][55][56][57][58][59][60].…”