Microwave activation coupled with solvent-free phase transfer catalysis (PTC), as a green chemistry procedure, was applied to the synthesis of new benzylidene cineole derivatives as potential UVA filters. Considerable improvements over classical procedures are put into evidence when using KOH + K2CO3 as the base and TBAB as the phase transfer agent. Comparison with conventional heating in strictly the same conditions as under microwave revealed an important specific non-thermal microwave effect. Preliminary studies to evaluate the photochemical behaviour of these new derivatives were carried out
Synopsis The synthesis of a series of alkyl and arylesters of 1,3,3,-trimethyl-2-oxabicyclo[2.2.2]octan-6-ols (2-cineolylols) is described. All cineole esters obtained were tested for their olfactive character; the esters derived from aryl acyl chlorides were odourless, while aliphatic esters showed interesting multipurpose aromas. Some of these compounds exhibited fruity, woody, green, pine oil and violet-like notes and some showed aromas interesting for foodstuffs. In vitro toxicity tests were carried out on the cyclopropyl ester of 2-cineolylols, the most promising of these compounds as a potential perfume ingredient. In this study, cultured mouse fibroblast L-929 and human keratinocyte NCTC 2544 cell lines were used. The results obtained with the evaluation of three different physiological end points showed that the tested compound possess much lower cytotoxicity than sodium dodecylsulphate (SDS) used as positive control.
Reaction of Ketenes with N,N-Disubstituted α-AminomethyleneKetones.Part 21. 2H-(1)Benzothiepino(5,4-b)pyran Derivatives with Local Anesthetic and Antiarrhythmic Activities.-Reaction of the aminomethylenedihydrobenzothiepinones (I) with phenylchloroketene, generated from chlorophenylacetic acid chloride (I) and triethylamine, followed by dehydrochlorination yields the aminodihydrobenzothiepinopyranones (III) mentioned in the title. (IIIb) has a local anesthetic effect higher than that of lidocaine, whereas ( IIIf) shows an antiarrhythmic activity in rats comparable to that quinidine. -(LONGOBARDI, M.; BARGAGNA, A.; MARIANI, E.; SCHENONE, P.; VITAGLIANO, S.; STELLA, L.; DI SARNO, A.; MARMO, E.; Farmaco, Ed. Sci.
Synopsis Semipermanent or direct colouring includes any product capable of affecting to some extent a change in the natural hair colour that will last through at least five shampoo washings. Semipermanent dyes are simple and easy to use, as opposed to oxidation dyes, and are normally formulated for application on nonbleached hair. Following increases in supply of such formulations, we have started an analysis for quality control purposes of 21 commonly marketed dyestuffs (nitroaminobenzenes, anthraquinone and Arianor dyes) and 20 colouring products manufactured by four leading companies. By using TLC (silica gel and reversed phase) and HPTLC (silica gel) procedures we have determined relative retention values to 1,3-diamino-4-nitrobenzene of standards and dyes found in the commercial products. All the values reported (standards and samples) are the average of five analytical results (+/-SD).
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