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The treatment measures of malignant carcinomas are most important for the progress of human health. In recent years the use of targeted therapy based on small molecules compounds and identical immunoglobulin are the most frequently used tools to combat cancerous cells. But there are still several limitations in their clinical development and applications of these technologies comprising their ability to bind multiple molecular target sites including both cell surface receptors and intracellular proteins and therefore promoting greater risk of toxicity. PROTAC a novel technology that work on maintaining balance between protein synthesis and degradation and make use of molecules instead of conventional enzyme inhibitor, containing two active domains and a linker to destroy unwanted selective protein (like kinase, skeleton protein and regulatory protein). PROTACs are the heterobifunctional nano molecules with size range of about 10 nanometres find application to eliminate the protein complexes formed by protein-protein interaction through large and flat surface generally defined as “undruggable” in conventional drug delivery system, which include around 85 % of proteins present in humans, suggesting their wide application in the field of drug development. Such peptide-based PROTACs have shown the destruction of targets in cultured cells successfully (e.g., MetAP-2, and FKBP12F36V, receptors for estrogens and androgen). However, some obstacles prevent this technology from transferring from the laboratory to its actual clinical utility, such as delivery system and bioavailability. The scope of the presented review is to gives an overview of novel PROTAC technology with its limitations, advantages , mechanism of action, development of photo-controlled PROTACs and to summarize its futuristic approach in targeting proteins in cancer cells.

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