“… 354 , 355 , 356 , 357 , 358 , 359 , 360 , 361 The widespread use of IAPs as an E3 ligase in TPD has drawn much attention from scientists in both academia and industry. 362 , 363 , 364 , 365 , 366 , 367 , 368 Correspondingly, many IAPs inhibitors were discovered and applied in the design of PROTAC degraders. 284 Specifically, the pink moiety is exposed to the solvent as a potentially ideal linking position in the design of PROTAC degraders, based on the crystal structure of IAPs inhibitor with IAPs protein (Figure 5 ; PDB ID: 5M6H).…”