Короткоцепочечные Жирные Кислоты: Роль В Развитии Синдрома Раздраженного Кишечника

Abstract

The article deals with the concepts of irritable bowel syndrome. A brief analysis of probable factors of irritable bowel syndrome development was performed. The role of intestinal microflora and the contribution of short-chain fatty acids to the processes occurring in the irritable bowel syndrosme are considered in detail. There were analyzed the studies of different authors concerning short-chain fatty acids. The results of own studies evaluating fecal content of shortchain fatty acids in patients with irritable bowel syndrome are shown. There was revealed a significant increase in the level of short-chain fatty acids, especially in diarrheal form of irritable bowel syndrome.

Peculiarities of the Effects of Bile Acids on Atpase Activity of the Colon Mucosa in Patients With Overweight and Irritable Bowel Syndrome

“…Previously, IBS was considered exclusively as a psychosomatic disease, and in almost all patients it was associated with the influence of psycho-emotional factors, but today the multifactorial development of IBS is obvious. Food allergies, stress, intes-tinal infections, hereditary predisposition, malabsorption, and disorders of bile acid metabolism are the major triggers for the development of IBS [6]. Bile acids are amphipathic, detergent molecules synthesized by the liver that facilitate the absorption of lipids and fat soluble vitamins in the small intestine.…”