Аутоантитела И Цитокиновый Профиль У Пациентов С Болезнью Грейвса И Эндокринной Офтальмопатией

Свириденко, Н. Ю.; России, Фгбу «Нмиц эндокринологии» Минздрава; Бессмертная, Е. Г.; Беловалова, И М; Mikheenkov, Alexander; Sheremeta, Marina S.; Nikankina, Larisa; Малышева, Н. М.

doi:10.14341/conf22-25.09.21-276

Cited by 4 publications

(9 citation statements)

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“…Концентрацию сердечного тропонина в сыворотке крови на анализаторе Architect i2000 методом хемилюминесцентного иммуноанализа на микрочастицах [2,8]. Степень выраженности застойной левожелудочковой недо-статочности кровообращения оценивали по размеру легочной вены (ЛВ) и правой ветви легочной артерии (ПВЛА) [10]. Характеристику ремоделирования сердца описывали по унифицированной методике [13,14].…”

Section: материалы и методы исследованияunclassified

“…Метаболические заболевания, например у высокопродуктивных коров могут инициировать развития гепатокардиального синдрома [8]. Считается, что системное воспаление, оксидативный стресс, эндогенная интоксикация, иммунные и аутоммунные процессы могут лежать в основе патогенеза развития гепатокардиальных осложнений у животных [9][10][11][12]. Гепатокардиальный синдром у кошек при первичной патологии миокарда, вызванного гипертрофической кардиомиопатий, не представлен в научной литературе.…”

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Features of the course of hepatocardial syndrome in cats with hypertrophic cardiomyopathy

Sotnikova,

Petrukhina,

Byakhova

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Agron. životnovod.

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The issues of changes in clinical, laboratory and instrumental parameters in cats with hepatocardial syndrome formed against the background of hypertrophic cardiomyopathy were studied. It is known that in high-bred cats with congestive heart failure, secondary hepatopathy can develop and progress. It was shown that hepatocardial syndrome occurs in 33.7 % of cats, out of the total number of patients with hypertrophic cardiomyopathy (n = 83). It has been established that hepatocardial complications in cats are a risk factor for a more severe course of hypertrophic cardiomyopathy. Hepatocardial syndrome in cats with hypertrophic cardiomyopathy is characterized by severe hypothermia, circulatory and respiratory failure. In sick animals, an increase in frequency of breathing during sleep was recorded (33.39.3 versus 17.91.8 times/min; p 0.001). Domestic cats with hepatocardial syndrome had a decrease in mean arterial blood pressure (100.219.3 versus 107.219.1 mm Hg; p 0.05), sinus tachycardia (200.319.6 17.8 times/min; p 0.001), which leads to a significant decrease in PQ intervals (57.99.9 versus 64.99.9 ms; p 0.001) and QT intervals (168.917, 2 vs 157.518.6 ms; p 0.001). Sick cats had a significant increase in the time of refilling of capillaries with blood, slowdown in intraventricular conduction, increase in voltage of ventricular and atrial complex on electrocardiograms, expansion of pulmonary vein, significant dilatation of left atrium, extreme concentric hypertrophy of left ventricle, increase in transverse contractility of myocardium of left ventricle and decrease in longitudinal contractility myocardium of left and right ventricles, cardiomyocyte cytolysis syndrome, cholestasis, and hypoalbuminemia

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Section: материалы и методы исследованияunclassified

unclassified

Features of the course of hepatocardial syndrome in cats with hypertrophic cardiomyopathy

Sotnikova,

Petrukhina,

Byakhova

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Agron. životnovod.

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“…Концентрацию билирубина в сыворотке крови измеряли колориметрическим методом. Оценку концентрации цитокинов в сыворотке крови проводили на фотометре Multiskan FC (Шанхай) со встроенным шейкером на 96 лунок при использовании спектрального диапазона 450 нм и тест систем для иммуноферментного анализа (интерферон-γ, интерлейкин-4, фактор некроза опухоли-α, интерлейкин-1α, интерлейкин-6, интерлейкина-8, (ООО «Цитокин», Россия) [10].…”

Section: материалы и методы исследованияunclassified

“…При осложнении первичного заболевания болевым синдромом степень нейтрофилии была достоверно выше [1,4]. При этом на фоне системной воспалительной реакции у больных гастроэнтеритом собак развиваются реологические изменения состава крови и диспротеинемия, что обусловливают повышение СОЭ [10].…”

Section: результаты исследований и обсуждениеunclassified

“…Ежегодно на территории Российской Федерации регистрируют около 1 млн случаев острых заболеваний у собак, сопровождающихся диареей, рвотой, гиповолемией, интоксикацией и нарушением функций многих систем организма [5,6]. Также следует отметить, что реальная заболеваемость животных гастроэнтеритом может быть гораздо выше официальной статистики за счет легких форм патологии, лечение которых проводится владельцами животных в домашних условиях [7][8][9][10]. Гастроэнтериты у собак сопровождаются альтеративными и воспалительными изменениями в стенке желудочно-кишечного тракта, часто осложняются болевым синдромом, интоксикацией, дегидратацией, гиповолемией, системными изменениями в организме, нарушениями моторной, секреторной, защитной, всасывательной и экскреторной функций кишечника и желудка [1,11].…”

Section: Introductionunclassified

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Pathogenetic factors associated with formation of acute abdominal pain syndrome in dogs with gastroenteritis

Karamyan,

Kuprina,

Lutsay

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Agron. životnovod.

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Intercorrelative relationships between various clinical and laboratory parameters in dogs with acute gastroenteritis were studied. In dogs with acute alimentary gastroenteritis (n = 31), pain rating scale score significantly (p 0.05) correlated with pulse rate (r = 0.58), respiratory rate (r = 0.50), hematocrit (r = 0.47), ESR (r = 0.72), number of erythrocytes (r = 0.50) and leukocytes (r = 0.77), concentration of albumins (r = -0.52), globulins (r = 0.59), 1-globulins (r = 0.49), 2-globulins (r = 0.42), -globulins (r = -0.36), -globulins (r = 0.59), C-reactive protein (r = 0.82), serum activity of ALT (r = 0.70), AST (r = 0.39), -amylase (r = 0.38), alkaline phosphatase (r = 0.83) and serum concentration of creatinine (r = 0.42), tumor necrosis factor- (r = 0.82), interleukin-4 (r = 0.92), interleukin-6 (r = 0.92), interferon- (r = 0.91), interleukin-1 (r = 0.85), interleukin-8 (r = 0.91). The following changes were noted in the body of dogs with acute gastroenteritis: local and systemic immune-inflammatory response activated, pain, intoxication, dehydration syndrome, disorders of motor, secretory, absorption, excretory function of gastrointestinal tract formed, secondary hepatopathy and pancreatopathy developed. In dogs with acute gastroenteritis, there were also statistically significant (p 0.05) correlations between the number of erythrocytes and hematocrit (r = 0.65), MCHC (r = 0.32), ESR (r = 0.35), hemoglobin concentration (r = 0.73) and leukocyte count (r = 0.35); between MCV and hematocrit (r = 0.62), MCHC (r = -0.64); between MCV and MCHC (r = -0.64); MCH and MCHC (r = 0.40); ESR and leukocyte count (r = 0.53). Changes in intercorrelative relationships between clinical and laboratory parameters in dogs with acute gastroenteritis can be considered as predictors of severity of the pathological process.

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Clinical and immunological predictors of Graves’ orbitopathy after radioiodine therapy of Graves’ disease

Sheremeta,

Bessmertnaya,

Elfimova

et al. 2023

Probl Endokrinol (Mosk)

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BACKGROUND: Data on the effect of 131I on the course of Graves’ orbitopathy (GO) are contradictory. A number of studies indicate a deterioration in the course of GO against the background of RAIT, in other studies such a connection has not been established. Cytokines that regulate inflammation could potentially be biomarkers for assessing GO activity and predicting the course of GO after RAIT.AIM: The purpose of this study was to evaluate the dynamics of eye symptoms and analyze immunological parameters: cytokine TGF-β1 and cytokine receptors: sTNFα-R1, sTNFα-R2, sIL-2R, sIL-6R over time after RAIT, as possible predictors of GO activation.MATERIALS AND METHODS: The study included 59 patients (118 orbits) with GD in the state of euthyroidism and subclinical hyperthyroidism and low active and inactive GO, aimed at conducting RAIT. Concentrations of cytokine TGF-β1, sTNFα-RI and sTNFα-R2, sIL-2R, sIL-6R, TSH receptor antibodies (rTSH-Ab), free thyroxine (FT4) and free triiodothyronine (FT3), thyroid-stimulating hormone (TSH) in the blood serum were determined. Ultrasound examination of the thyroid gland, multispiral computed tomography (MSCT)/magnetic resonance imaging (MRI) of the orbits was performed. The examination was carried out 3, 6, 12 months after the RAIT.RESULTS: The deterioration of the course of the GO (1–2 points according to CAS) was noted after 3 months. (32.5%) and to a lesser degree after 6 and 12 months (13.2% and 8.45%, respectively). Dynamics were not noted, approximately, in the same number of patients (40.5%, 41.5%, 45.8%, respectively). An improvement in the course of the GO was noted after 6 and 12 months (45.3, 45.8, respectively). After 3 and 6 months, the achievement of hypothyroidism and a significant increase in the level of rTSH-Ab were noted. In the analysis of cytokines and their receptors a significant decrease in the level of TGF-β1 was noted after 3, 6 and 12 months. There was also a significant decrease in sTNF-R1 and sIL-2R at 3 and 6 months. The level of sTNFα-R2 significantly decreased 3 months after RAIT. The level of sIL-6R has not changed significantly. After 3 months in patients with positive dynamics of image intensification, the level of TGF-β1 did not significantly change compared with the level before RAIT, in patients with worsening of the course of GO or without dynamics, the level of TGF-β1 significantly decreased. After 6 months, there was the same trend, not reaching statistical significance. The IgG4 level and the IgG4/IgG ratio increased to 6 and 12 months, which corresponded to an increase in diplopia index.CONCLUSION: The main limiting factor in the conduct of RAIT is the activity of the autoimmune process in the orbits. Since patients with inactive (CAS 0–2) or low activity (CAS 3–4) GO were referred for RAIT, there was no pronounced activation of GO after RAIT. There was a slight deterioration in the course of GO by only 1–2 points according to CAS after 3 months. (32.5%) and to a lesser degree after 6 months (13.2%). In the study, it was found that the main predictors of the deterioration of the course of GO after RAIT are uncompensated hypothyroidism, a high level of rTSH-Ab and a decrease in the level of cytokine TGF-β1.

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Аутоантитела И Цитокиновый Профиль У Пациентов С Болезнью Грейвса И Эндокринной Офтальмопатией

Cited by 4 publications

References 0 publications

Features of the course of hepatocardial syndrome in cats with hypertrophic cardiomyopathy

Features of the course of hepatocardial syndrome in cats with hypertrophic cardiomyopathy

Pathogenetic factors associated with formation of acute abdominal pain syndrome in dogs with gastroenteritis

Clinical and immunological predictors of Graves’ orbitopathy after radioiodine therapy of Graves’ disease

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