Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties

Abstract

Tetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

“…c) Structures of two porphyrin PDT agents covalently linked by ssDNA aptamers. Reproduced with permission . Copyright 2017, World Scientific Publishing Co. Pte.…”

“…Unfortunately, this strategy is prone to enzymatic degradation in the blood circulation . Aptamers were also conjugated to functional materials by an amide linker or sulfonamide linker . However, complementary base pairing for conjugating aptamers to materials was shown as an effective alternative strategy for in vivo applications with appropriate stability .…”

“…PDT agents have also been developed using Zn-porphyrin complexes for targeted transmembrane tyrosine kinase receptor HER2 sensing with simultaneous breast cancer therapeutic potential (Figure 16c). [167]…”

“…Reproduced with permission. [167] Copyright 2017, World Scientific Publishing Co. Pte. Ltd. Figure 17.…”

“…[52,125] Aptamers were also conjugated to functional materials by an amide linker [143] or sulfonamide linker. [167] However, complementary base pairing for conjugating aptamers to materials was shown as an effective alternative strategy for in vivo applications with appropriate stability. [138,144,158] Non-covalent methods were also employed to coat aptamers to the surface of 2D MoS 2 flakes.…”