The effects of the composition and structure of quantum dots combined with cobalt phthalocyanine and an aptamer on the electrochemical detection of prostate specific antigen

Nxele, Siphesihle Robin; Nyokong, Tebello

doi:10.1016/j.dyepig.2021.109407

Cited by 15 publications

(6 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the optimum operation and minimal interference in mixed samples are evidenced by the outstanding performance of all sensors manufactured with the NGQDs‐based aptasensor. Similar to the concentration of PSA in buffer (0.044 ng/mL), the LOD was determined to be 0.043 ng/mL in men with prostate cancer, 104 which is still below the cutoff value (4 ng/mL) in these patients 105 …”

Section: Qd‐apt Conjugates For Cancer Managementmentioning

confidence: 99%

“…The arrow indicates an increase in PSA concentrations. 104 DOX QD-Apt. 37 Therefore, it can be applied to imaging prostate cancer cells and simultaneously deliver chemotherapeutic agents to these cells.…”

Section: ) (C) This Model Is Based Onmentioning

confidence: 99%

“…There was a linear association between R ct and concentration. The arrow indicates an increase in PSA concentrations 104 …”

Section: Qd‐apt Conjugates For Cancer Managementmentioning

confidence: 99%

See 2 more Smart Citations

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Davodabadi

Mirinejad

Fathi-karkan

et al. 2023

Biotechnology Progress

View full text Add to dashboard Cite

Aptamers (Apts) are synthetic nucleic acid ligands that can be engineered to target various molecules, including amino acids, proteins, and pharmaceuticals. Through a series of adsorption, recovery, and amplification steps, Apts are extracted from combinatorial libraries of synthesized nucleic acids. Using aptasensors in bioanalysis and biomedicine can be improved by combining them with nanomaterials. Moreover, Apt‐associated nanomaterials, including liposomes, polymeric, dendrimers, carbon nanomaterials, silica, nanorods, magnetic NPs, and quantum dots (QDs), have been widely used as promising nanotools in biomedicine. Following surface modifications and conjugation with appropriate functional groups, these nanomaterials can be successfully used in aptasensing. Advanced biological assays can use Apts immobilized on QD surfaces through physical interaction and chemical bonding. Accordingly, modern QD aptasensing platforms rely on interactions between QDs, Apts, and targets to detect them. QD‐Apt conjugates can be used to directly detect prostate, ovarian, colorectal, and lung cancers or simultaneously detect biomarkers associated with these malignancies. Tenascin‐C, mucin 1, prostate‐specific antigen, prostate‐specific membrane antigen, nucleolin, growth factors, and exosomes are among the cancer biomarkers that can be sensitively detected using such bioconjugates. Furthermore, Apt‐conjugated QDs have shown great potential for controlling bacterial infections such as Bacillus thuringiensis, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, Campylobacter jejuni, Staphylococcus aureus, and Salmonella typhimurium. This comprehensive review discusses recent advancements in the design of QD‐Apt bioconjugates and their applications in cancer and bacterial theranostics.

show abstract

Section: Qd‐apt Conjugates For Cancer Managementmentioning

confidence: 99%

Section: ) (C) This Model Is Based Onmentioning

confidence: 99%

See 1 more Smart Citation

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Davodabadi

Mirinejad

Fathi-karkan

et al. 2023

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…The literature shows that GQDs are a great platform for the specific and sensitive recognition of biomarkers, which are highly synergistic with electrochemical sensors. 303 Recently Nxele et al developed an aptasensor for the electrochemical detection of the prostate specific antigen (PSA) using different combinations of aptamer, CoPc, and GQD modified on a glass carbon electrode (GCS). The best efficacy was obtained by the GCE-GQD-CoPc (π-π)-aptamer with an LOD of 3.66 pM determined by electrochemical impedance spectroscopy (EIS) and 0.66 pM by differential pulse voltammetry (DPV).…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Graphene quantum dot-porphyrin/phthalocyanine multifunctional hybrid systems: from interfacial dialogue to application

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In recent works, exciting applications surrounding QDs have also been conducted. Due to their outstanding optical properties, QDs can be used for cancer cell imaging [39,40]. A review article on biomedical and drugs administration mediated by QDs was developed in [41].…”

Section: Introductionmentioning

confidence: 99%

Shallow Donor Impurity States with Excitonic Contribution in GaAs/AlGaAs and CdTe/CdSe Truncated Conical Quantum Dots under Applied Magnetic Field

et al. 2021

View full text Add to dashboard Cite

Using the effective mass approximation in a parabolic two-band model, we studied the effects of the geometrical parameters, on the electron and hole states, in two truncated conical quantum dots: (i) GaAs-(Ga,Al)As in the presence of a shallow donor impurity and under an applied magnetic field and (ii) CdSe–CdTe core–shell type-II quantum dot. For the first system, the impurity position and the applied magnetic field direction were chosen to preserve the system’s azimuthal symmetry. The finite element method obtains the solution of the Schrödinger equations for electron or hole with or without impurity with an adaptive discretization of a triangular mesh. The interaction of the electron and hole states is calculated in a first-order perturbative approximation. This study shows that the magnetic field and donor impurities are relevant factors in the optoelectronic properties of conical quantum dots. Additionally, for the CdSe–CdTe quantum dot, where, again, the axial symmetry is preserved, a switch between direct and indirect exciton is possible to be controlled through geometry.

show abstract

The effects of the composition and structure of quantum dots combined with cobalt phthalocyanine and an aptamer on the electrochemical detection of prostate specific antigen

Cited by 15 publications

References 58 publications

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Graphene quantum dot-porphyrin/phthalocyanine multifunctional hybrid systems: from interfacial dialogue to application

Shallow Donor Impurity States with Excitonic Contribution in GaAs/AlGaAs and CdTe/CdSe Truncated Conical Quantum Dots under Applied Magnetic Field

Contact Info

Product

Resources

About