Zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing

Chen, Yuting; Cai, Jinhong; Liu, Shuhan; Lei, Doudou; Zheng, Li; Wei, Qingjun; Gao, Ming

doi:10.1093/rb/rbac019

Cited by 56 publications

(43 citation statements)

References 44 publications

(46 reference statements)

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“…193 Due to the bactericidal ability of metal ions such as Ag + , Zn 2+ , and Cu 2+ , NNPH with MOFs based nanomaterials serving nanofillers have also been studied for wound healing applications. [194][195][196] Deng et al reported an injectable biomimetic NNPH using metal-organic frameworks (MOFs) encapsulating with Au nanoparticles (Au@ZIF-8) and hydrogels prepared between carbohydrazidemodified GelMa and oxidized sodium alginate through Schiff-base as well as photo crosslinking. The NNPH displayed photodynamic bactericidal performance, with >99.0% of bacteria eradicated after light exposure (generating ROS) for 20 minutes.…”

Section: Metal-based Nanomaterials Of Nnphs For Wound Healingmentioning

confidence: 99%

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

et al. 2023

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Section: Metal-based Nanomaterials Of Nnphs For Wound Healingmentioning

confidence: 99%

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

et al. 2023

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“…For example, Gao et al . prepared nanosized zinc-based metal–organic frameworks (MOFs) with favorable antibacterial and anti-inflammatory properties via slowly releasing Zn ions [ 66 ]. Some metallic materials can be utilized in tumor ablation for their superior photothermal conversion efficiency [ 67 ].…”

Section: The Different Sources Of Biomaterials For Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

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Nowadays, biomaterials have evolved from the inert supports or functional substitutes, to the bioactive materials able to trigger or promote the regenerative potential of tissues. The interdisciplinary progress has broadened the definition of “biomaterials”, and a typical new insight is the concept of tissue induction biomaterials. The term “regenerative biomaterials” and thus the contents of the present paper are relevant to yet beyond tissue induction biomaterials. This review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers, and bio-derived materials. As the application aspects are concerned, this paper introduces regenerative biomaterials for bone and cartilage regeneration, cardiovascular repair, three dimensional bioprinting, wound healing, and medical cosmetology. Cell-biomaterial interactions are highlighted. Since the global pandemic of COVID-19, the review particularly mentions biomaterials for public health emergency. In the last section, perspectives are suggested: (1) Creation of new materials is the source of innovation; (2) Modification of existing materials is an effective strategy for performance improvement; (3) Biomaterial degradation and tissue regeneration are required to be harmonious with each other; (4) Host responses can significantly influence the clinical outcomes; (5) The long-term outcomes should be paid more attention to; (6) The non-invasive approaches for monitoring in vivo dynamic evolution are required to be developed; (7) Public health emergencies call for more research & development of biomaterials; (8) Clinical translation needs to be pushed forward in a full-chain way. In the future, more new insights are expected to be shed into the brilliant field — regenerative biomaterials.

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“…Compared with traditional inorganic polymers (mesoporous silica) [ 112 , 113 ], hollow polymeric nanosphere (HPN) [ 114 ], porous organic polymers [ 115 ] (covalent organic frameworks (COF) [ 116 , 117 ], hypercrosslinked polymers (HCP) [ 118 ], inherently microporous polymers (PIM) [ 119 ], porous aromatic frameworks (PAF) [ 120 ], conjugated microporous polymers (CMP) [ 121 ], and other biodegradable polymers (polypeptides) [ 122 , 123 ], MOF-based composites offer great opportunities for multifunctionalization by virtue of their unique organic–inorganic hybrid composite structures, ordered porous structures, and high biocompatibility [ 124 ]. When dealing with complex wounds, MOFs can achieve wound healing effects by releasing metal ions and loading drugs, including regulating the oxidative stress response, antibacterial effects, and promoting angiogenesis, collagen deposition, and re-epithelialization [ 125 , 126 , 127 ], by improving wound site infection and blood flow reperfusion to accelerate the wound healing process and restore normal skin function ( Table 2 ).…”

Section: Application Of Mofs In Wound Healingmentioning

confidence: 99%

Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

et al. 2022

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Diabetes-related chronic wounds are often accompanied by a poor wound-healing environment such as high glucose, recurrent infections, and inflammation, and standard wound treatments are fairly limited in their ability to heal these wounds. Metal–organic frameworks (MOFs) have been developed to improve therapeutic outcomes due to their ease of engineering, surface functionalization, and therapeutic properties. In this review, we summarize the different synthesis methods of MOFs and conduct a comprehensive review of the latest research progress of MOFs in the treatment of diabetes and its wounds. State-of-the-art in vivo oral hypoglycemic strategies and the in vitro diagnosis of diabetes are enumerated and different antimicrobial strategies (including physical contact, oxidative stress, photothermal, and related ions or ligands) and provascular strategies for the treatment of diabetic wounds are compared. It focuses on the connections and differences between different applications of MOFs as well as possible directions for improvement. Finally, the potential toxicity of MOFs is also an issue that we cannot ignore.

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Zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing

Cited by 56 publications

References 44 publications

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

Recent advances in regenerative biomaterials

Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

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