Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

Wang, Min; Deng, Zexing; Guo, Yi; Zheng, Haishi

doi:10.1039/d2na00700b

Cited by 29 publications

(16 citation statements)

References 214 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both natural biopolymers (e.g., alginate, cellulose, gelatin, and others) and synthetic polymers (e.g., poly (lactic-co-glycolic acid), polylactide, polyurethane, and others) have been utilized to produce effective hybrid scaffolds for wound management. [108,109] However, the loading of effective and safe antibacterial medications into the polymer matrix still perplexes researchers. Li et al recently developed a supramolecular guanosine-quadruplex (G4)-hydrogel as a container for generating ROS from glucose.…”

Section: Polymers As Carriers In Antibacterial Therapymentioning

confidence: 99%

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy

Jing

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Diabetic foot ulcer (DFU), a common complication of diabetes, has become a great burden to both patients and the society. The delayed wound closure of ulcer sites resulting from vascular damage and neutrophil dysfunction facilitates bacterial infection. Once drug resistance occurs or bacterial biofilm is formed, conventional therapy tends to fail and amputation is unavoidable. Therefore, effective antibacterial treatment beyond antibiotics is of utmost importance to accelerate the wound healing process and prevent amputation. Considering the complexity of multidrug resistance, biofilm formation, and special microenvironments (such as hyperglycemia, hypoxia, and abnormal pH value) at the infected site of DFU, several antibacterial agents and different mechanisms have been explored to achieve the desired outcome. The present review focuses on the recent progress of antibacterial treatments, including metal‐based medications, natural and synthesized antimicrobial peptides, antibacterial polymers, and sensitizer‐based therapy. This review provides a valuable reference for the innovation of antibacterial material design for DFU therapy.

show abstract

Section: Polymers As Carriers In Antibacterial Therapymentioning

confidence: 99%

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy

Jing

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…138 Nano composites could provide enhanced mechanical, antibacterial, antioxidant, anti-inflammatory, stimuli-responsive, and electrically conductive properties of hydrogels. 139 Numerous promising fields, such as biomedical devices, wound healing, medication delivery, magnetic resonance imaging (MRI), and wastewater treatment, can benefit from using magnetic hydrogels as described in different sections of this paper. [140][141][142][143] There are two distinct functions associated with MNPs such as iron oxide.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

“…To create nanocomposites with better characteristics and customized functionality, various nanoparticles, including polymeric, carbon‐based, ceramic, and metallic nanomaterials, can be added inside the hydrogel networks 138 . Nano composites could provide enhanced mechanical, antibacterial, antioxidant, anti‐inflammatory, stimuli‐responsive, and electrically conductive properties of hydrogels 139 . Numerous promising fields, such as biomedical devices, wound healing, medication delivery, magnetic resonance imaging (MRI), and wastewater treatment, can benefit from using magnetic hydrogels as described in different sections of this paper 140–143 .…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

Mollajavadi,

Tarigheh,

Eslami‐Farsani

2023

Polymer Composites

View full text Add to dashboard Cite

Materials that can recover the function of lost or damaged parts, called self‐healing materials, have attracted attention due to their wide usage in different fields such as water refinery, coatings, robotics, and especially, biomedical applications. Depending on whether the self‐healing component is added to the polymer or is inherent to the polymeric matrix, the self‐healing properties of the polymeric materials can be classified into extrinsic and intrinsic self‐healing. Hydrogels are one of the most used polymers in self‐healing applications for various purposes, including tissue engineering, drug delivery, etc. Nanoparticles can endow some essential features to hydrogels, such as improving mechanical properties, more efficient healing ability, conductivity, and antibacterial and magnetic features. In the current study, various biomedical applications of self‐healing polymers using nanoparticles are discussed in detail, showing the impact of addition of nanoparticles. Perfect antibacterial properties with the addition of copper sulfide or silver nanoparticles were achieved. In addition, enhancing compression modulus up to three times and endowing conductivity to the hydrogel as the effect of carbon nanotube addition and better mechanical properties caused by graphene oxide and iron oxide nanoparticles were reported. These are just a few examples of the results achieved by adding nanoparticles to the self‐healing polymers described in this study.

show abstract

“…Among them, chitosan (CS) is a typically natural polymer with certain antibacterial activity and high biocompatibility, which is obtained by alkaline deacetylation of chitin. 221–224 The antibacterial mechanism of chitosan is that its amino groups form cationic groups at pH below its p K a , and these cationic groups can electrostatically interact with bacterial cell walls to alter the permeability of the microbial cell membrane. The amino groups can also be functionalized by an amidation reaction to improve the antibacterial effects of the CS.…”

Section: Nanobactericides Against Mdr Bacteriamentioning

confidence: 99%

Recent advances in nanoantibiotics against multidrug-resistant bacteria

Li,

Liu,

Gong

et al. 2023

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

Abstract: Skin injury occurs due to acute trauma, chronic trauma, infection, and surgical intervention, which can result in severe dysfunction and even death in humans. Therefore, clinical intervention is critical...

Cited by 29 publications

References 214 publications

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

Recent advances in nanoantibiotics against multidrug-resistant bacteria

Contact Info

Product

Resources

About