Zein/soluble soybean polysaccharide composite nanoparticles for encapsulation and oral delivery of lutein

Li, Hao; Yuan, Yongkai; Zhu, Junxiang; Wang, Teng; Wang, Dongfeng; Xu, Ying

doi:10.1016/j.foodhyd.2020.105715

Cited by 128 publications

(53 citation statements)

References 62 publications

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“…This is due to the continuous stirring and electrostatic interaction that broke the F molecules. Further increasing the ratio to 1:1 induced a new morphology in the polysaccharide particles with stronger binding, caused by the electrostatic interactions between molecules 29 . Notably, the composite particles in ChN 1 ‐F 1 ‐pH 2 were connected by a fiber bridge that formed a porous network structure because the abundance of protonated nanocrystals and ionized F increased at a pH of 2, and the exposed –NH 3 + and –OSO 3 − combined electrostatically to promote intermolecular interactions 20 .…”

Section: Resultsmentioning

confidence: 99%

Oil‐in‐water Pickering emulsion stabilization with oppositely charged polysaccharide particles: chitin nanocrystals/fucoidan complexes

Liu

Zhang

et al. 2020

J Sci Food Agric

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BACKGROUND Chitin nanocrystals (ChN) are insoluble particles that can be used as stabilizers for Pickering emulsions. Their unique cationic properties and antibacterial activity have generated considerable interest among researchers. However, ChN have remained largely underexplored. Furthermore, the droplets of the emulsions stabilized by ChN are as large as 10–100 μm, and their physical stability requires further improvement. Some studies have shown that the spontaneous reaction of oppositely charged particles can effectively stabilize the emulsions. Positively charged ChN and negatively charged fucoidan (F) were therefore compounded to stabilize Pickering emulsions, and the stability of these emulsions was analyzed qualitatively. RESULTS The results showed that the composite particles comprising two polysaccharides in a mass ratio of 1:1 and at a pH of 2 (ChN1‐F1‐pH 2) possessed the lowest sulfate content (20.1%) and almost zero potential (−3 mV), indicating a high degree of neutralization of the positively charged amino group in ChN and the negatively charged sulfate group in F. Meanwhile, ChN1‐F1‐pH 2 displayed a dense network structure that improved the dispersibility and wettability (contact angle = 9.3°). Fourier transform infrared spectroscopy results confirmed that ChN and F were effectively combined through electrostatic interaction or neutralization to produce a polyelectrolyte complex. Furthermore, the particle size of the Pickering emulsion stabilized by ChN‐F was significantly reduced, and the maximum size did not exceed 10 μm; the physical and storage stability also improved. The ChN1‐F1‐pH 2 emulsion presented excellent storage stability; in particular, the emulsions stabilized by ChN1‐F1‐pH 5 and ChN1‐F1‐pH 6 exhibited excellent flocculation stabilities. CONCLUSION The size of the emulsion droplets stabilized by the oppositely charged polysaccharide particles (ChN‐F complexes) reduced significantly. Furthermore, by changing the mass ratio and pH, the microstructure and binding degree of the complexes can be adjusted, thereby promoting their adsorption on the oil–water interface and improving the stability of the Pickering emulsion. © 2020 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Oil‐in‐water Pickering emulsion stabilization with oppositely charged polysaccharide particles: chitin nanocrystals/fucoidan complexes

Liu

Zhang

et al. 2020

J Sci Food Agric

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“…Application Encapsulated Substance Reference zein/chitosan nano complex oral drug and food delivery curcumin and resveratrol [97] zein/carrageenan oral drug delivery curcumin and piperine coenzyme Q10 and piperine [98,99] hydrophilic whey isolate/zein oral drug delivery curcumin [100] zein/carrageenan/tween 80 drug delivery curcumin [101] pectin from Akebia trifoliata var. Australis fruit peel and zein drug and food delivery curcumin [102] deamidated zein peptide drug and food delivery curcumin [37] zein/soybean polysaccharide drug delivery lutein [103] zein/caseinate oral and parenteral drug delivery simvastatin [44] zein/gold nanoparticles antibacterial and larvicidal the whole nanocomposite [104] zein/lactoferrin drug delivery 7,8-dihydroxyflavone [105] zein/tea saponins food and drug delivery lutein [106] solid zein nanoparticles drug delivery Gene delivery maytansine PTEN and TRAIL genes [107,108] hollow zein nanoparticles food and drug delivery curcumin [109] zein/CMC postharvest fruit preservation natamycin [56] zein/bacterial cellulose preservative and packaging silymarin [110] zein/sodium deoxycholate cytotoxic drug delivery paclitaxel [111] lipid/zein core-shell nanocomposite targeted pulmonary drug delivery all-trans retinoic acid and genistein [112] mesoporous silica nanoparticles coated with zein polycarbolactone mixture antimicrobial photodynamic therapy methylene blue [113] zein/phosphatidylcholine hybrid nanoparticles cancer photodynamic therapy indocyanine green [114] zein/lactoferrin functional food delivery 7,8-dihydroxyflavone [105] zein/hyaluronic acid targeted drug delivery curcumin honokiol [115,116] zein-cellulose nanocrystals core-shell nanoparticles functional food delivery curcumin [117] zein nanoparticles oral drug delivery resveratrol [118] polyamine modified zein pest management avermectin [119] zein/pluronic F68 nanoparticles pest management limonene and carvacrol [120] zein/fucoidan nanocomplex oral drug delivery curcumin…”

Section: Zein Based Nanocomposite Platformmentioning

confidence: 99%

Surface-Tailored Zein Nanoparticles: Strategies and Applications

et al. 2021

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Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

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“…The higher volume to surface ratio is also one of the important factors required for favorable intestinal absorption of carotenoids [12,29]. A recent report on lutein nanoencapsulation using zein/soluble soybean polysaccharide composites has shown that the aqueous solubility of lutein (64.40 µg/mL) was enhanced over 30-fold in comparison to free lutein [30]. In contrast, to their report, the present study showed that the lutein-NEL (120 µg/mL) exhibits 72.6% higher solubility.…”

Section: Aqueous Solubility Of the Lutein-nelmentioning

confidence: 99%

Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of retinal protective carotenoid lutein in rat model

Toragall

Godhwani

Baskaran

et al. 2021

Preprint

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There is excessive interest in emerging colloidal delivery systems to enhance the water solubility and oral bioavailability of lutein, which is a hydrophobic carotenoid claimed to possess health benefits. The present study aimed to design lutein-enriched nanoemulsions with improved physicochemical properties and to achieve various health benefits of lutein. The prepared lutein nanoemulsion was characterized, and its bioavailability was examined in vitro (simulated gastrointestinal digestion) and in vivo. The mean size, PDI and zeta potential of the lutein nanoemulsion were 110 ± 8 nm, 0.271 and 36 ± 2 mV, respectively. Furthermore, TEM examination revealed that the particles are nanosized and spherical in shape. Notably, the aqueous solubility of the nanoemulsion was 726-fold higher than that of free lutein. The composite nanoemulsion also showed exceptionally higher (87.4%) in vitro bioaccessibility than that of nonencapsulated or free lutein (15%). The in vivo bioavailability of lutein nanoemulsion (112.6 ng/mL) was much higher than that of nonencapsulated lutein (48.6 ng/ml) and mixed micelles (68.5 ng/mL), and the tissue distribution pattern of lutein nanoemulsion showed higher lutein accumulation in the liver (2.80- and 1.70-fold) and eye (1.91- and 1.48-fold) compared to free lutein and mixed micelle-fed groups. These results suggested that oleic acid-linoleic acid composite nanoemulsions may be a promising delivery system for lutein and may help enhance the solubility, oral bioavailability and bioefficacy of lutein and could be used as an ingredient for the formulation of beverages or functional foods.

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Zein/soluble soybean polysaccharide composite nanoparticles for encapsulation and oral delivery of lutein

Cited by 128 publications

References 62 publications

Oil‐in‐water Pickering emulsion stabilization with oppositely charged polysaccharide particles: chitin nanocrystals/fucoidan complexes

Oil‐in‐water Pickering emulsion stabilization with oppositely charged polysaccharide particles: chitin nanocrystals/fucoidan complexes

Surface-Tailored Zein Nanoparticles: Strategies and Applications

Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of retinal protective carotenoid lutein in rat model

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