X-Ray Studies on Phospholipid Bilayers. XII. Interactions of Pentachlorophenol with Myelin

Abstract

Pentachlorophenol (PCP) is a widely used pesticide, particularly for the preservation of wood. Given its high toxicity and resistance to degradation it has become a dangerous environmental pollulant. Due to its high lipophilicity, PCP is able to partition into the lipid bilayer of cell membranes disrupting several vital functions. The present research was concerned with the effects that the chronic administration of PCP could produce in vivo to the sciatic nerve of rats. X-ray diffraction patterns obtained from freshly dissected and dried sciatic nerves of PCP treated rats did not show significant differences in their reflections with respect to those present in the patterns from untreated animals. However, morphological studies performed by optical and electron microscopy showed degenerative changes in about 10% of the A and B type of nerve fibers.

Stoffmonografie Chlorphenole ? Referenzwerte

“…Hemmung der Na + /K + -ATPase oder des Glucose-Transportes[49] können die Folge sein. Suwalsky et al[50] wiesen bei Ratten licht-und elektronenmikroskopisch degenerative Myelinveränderungen nach.Die Symptome erhöhter Stoffwechselaktivität und gesteigerten Sauerstoffverbrauchs sind also durch Energiemangel, das heißt, Verminderung des intrazellulären ATP-Gehaltes, bedingt. Kompensatorisch kommt es durch den Pasteur-Effekt zur Steigerung der Glykolyse.…”