Wound Healing and Blood Sugar Effect of Psidium guajava L. Leaves and Melastoma malabathricum L. Leaves on Rats with Diabetic Foot Ulcer

THE EFFECTIVENESS OF GUAVA (Psidium guajava) AND SENDUDUK LEAVES (Melastoma malabathricum L.) EXTRACT GEL TOWARDS THE INFLAMMATION MARKERS AND COLLAGENS ON INDUCED MALE RATS (SPRAGUE DAWLEY) WITH DIABETES

“…These substances contain active components of antioxidants, which the mixed extracts lead to significant improvement in wound healing (Bhangale & Acharya 2014;Durkar et al 2014;Bouaziz-Ketata et al, 2015;Mamta et al, 2015;Bhatt & Patel 2015;Chandra et al 2015). Ulcer wounds on rats' feet were better when compared to other treatment groups (Maigoda et al, 2019).…”

“…Melastoma malabathricum L. and Psidium guajava leave contain a rich amount of flavonoids, alkaloids, tannins, saponins, quinones, steroids, and triterpenoids (Maigoda et al 2019). These substances contain active components of antioxidants, which the mixed extracts lead to significant improvement in wound healing (Bhangale & Acharya 2014;Durkar et al 2014;Bouaziz-Ketata et al, 2015;Mamta et al, 2015;Bhatt & Patel 2015;Chandra et al 2015).…”

“…Both of these leaves are often used to treat diabetic wounds as traditional medicine. A study has shown that the mixed extracts of Melastoma malabathricum L. and Psidium guajava leaves had the potential to heal wounds significantly (p<0.001) by reducing the wide parameter of diabetic foot wounds in rats compared to other groups (Maigoda et al, 2019). Nonetheless, data remain unknown related to inflammatory markers and collagen formation.…”

Anti-Microbial Activity and Diabetic Wound Healing Effects of Psidium Guava and Melastoma Malabathricum Linn Leaves Gel in Rats (Sprague Dawley)

“…In vitro, the bioactive components of the extract are flavonoids, tannins, steroid saponins, total phenol 6.08%, quercetin 0.31 mg and antioxidant activity> 31.25 ppm in a mixed extract of Psidium guajava L and Melastoma malabathricum L (Maigoda, 2019). The treatment effects of the test preparation on the diameter of the rat wound in four treatments in each group is shown in Table 2.…”

“…Melastoma malabathricum linn leaves is a plant that grows wild and can survive on dry and infertile soil. The melastoma malabathricum linn leaves have known chemical contents, namely flavonoids, tannins, saponins, glycosides, and steroids or triterpenoids (Mittal, 2010;Maigoda et al, 2019) Melastoma malabathricum linn or senduduk leaves is a herbaceous plant of the Melastomataceae family and herbal plants widely used in traditional medicine to treat inflamed wounds. The leaf extract has antibacterial activity isolated from different clinical wounds against S.aureus and P.aeruginosa and gave MICs ranging from 3.0 mg/ml for 3 of the 4 clinical strains of S. aureus to 8.0 mg/ml for all 3 strains of S. aureus, and strains of P. aeruginosa were tested.…”