Women with inoperable or locally advanced breast cancer – what characterizes them? A retrospective review of 157 cases

El-Charnoubi, Waseem Asim Ghulam; Svendsen, Jesper Brink; Tange, Ulla Brix; Kroman, Niels

doi:10.3109/0284186x.2012.707788

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…The evidence on the effects of chronic diseases on cancer stage is mixed, with some studies indicating an association with advanced stage [19][20][21][22][23][24][25][26][27][28][29][30][31] , others showing no effect [32][33][34] and some reporting a reduced risk of advanced stage 19,22,25,28,31,34,35 for patients with chronic diseases (Figure 1). Hereafter we report estimates only if statistically significant.…”

Section: Cancer Stage At Diagnosismentioning

confidence: 99%

Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms

et al. 2019

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Section: Cancer Stage At Diagnosismentioning

confidence: 99%

Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms

et al. 2019

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“…They showed that despite equal access to cancer care-related services, common explanations for nonadherence included limited knowledge about preventive or cancer care resources and denial or fear. Furthermore, it appears that women with locally advanced breast cancer are more likely to suffer from psychiatric comorbidity and more often live alone [ 15 ]. In our case, the melancholic episode may have delayed the diagnosis of soft tissue metastases, due to the denial of imaging and medical treatment of the patient.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review

Foucher

Roussel

Hivelin

et al. 2017

Case Reports in Obstetrics and Gynecology

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Malignant phyllodes tumors (MPT) are rare breast neoplasms. Preoperative diagnosis is often challenging due to the unspecific clinical, radiological, and histological characteristics of the tumor. Dissemination pathways are local with chest wall invasion, regional with lymph nodes metastasis, and distant, hematogenous, mostly to the lungs, bones, and brain. Distant metastasis (DM) can be synchronous or appear months to years after the diagnosis and initial management. The current report describes the case of a 57-year-old woman presenting with a giant/neglected MPT of the breast, with no DM at initial staging, treated by radical modified mastectomy. Motor disorders due to medullar compression by a paravertebral mass appeared at short follow-up, also treated surgically. The patient died from several DM of rapid evolution. To our knowledge, this is the only case described of MPT with metastases to soft tissue causing medullar compression. We present a literature review on unusual metastatic localizations of MPT.

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Histopathological characterization of ulcerated breast cancer and comparison to their non-ulcerated counterparts

et al. 2014

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Approximately 6-15 % of breast cancer patients are diagnosed with primary ulcerated breast cancer (ULBC). ULBC is known to be associated with short recurrence free and poor overall survival. Therefore, the purpose of this study was to characterize ULBC and compare the histopathological findings with those of non-ulcerative breast cancer (NULBC). A total of 152 ULBCs were evaluated and compared to 304 consecutive non-ulcerated, age-matched breast malignancies. Patients mean age was 65 years (SD = 13.0 ULBC, SD = 14.0 NULBC). ULBC was associated with a higher rate of poorly differentiated tumors (p = < 0.001), as well as larger tumor sizes (p = < 0.001). As expected, the rate of axillary lymph node involvement was higher in ULBC patients (p = <0.001). In addition to that, ULBC was associated with a higher rate of triple negative breast cancer (p = 0.002), and higher Ki67 expression (p = < 0.001). ULBC showed more aggressive histopathological features in comparison to NULBC which may contribute to the generally known poorer prognosis of women with ULBC.

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Women with inoperable or locally advanced breast cancer – what characterizes them? A retrospective review of 157 cases

Cited by 8 publications

References 17 publications

Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms

Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms

Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review

Histopathological characterization of ulcerated breast cancer and comparison to their non-ulcerated counterparts

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