Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review

Foucher, Tiphaine de; Roussel, H.; Hivelin, Mikaël; Rossi, L.; Cornou, C.; Bats, Anne‐Sophie; Deloménie, M; Lécuru, Fabrice; Ngô, Charlotte

doi:10.1155/2017/8963013

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…TNBC accounts for ~15% of breast cancers and is characterized by loss of expression of estrogen receptor, progesterone receptor and HER2 ( 2 , 3 ). Local invasion and distant spread are the main causes of tumor progression ( 4 ). Although surgery and chemotherapy are effective, they still fail to meet expectations ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway

Yao

Tian

2022

Exp Ther Med

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Breast cancer is a highly heterogeneous tumor, among which triple negative breast cancer (TNBC) is the most invasive and prone to recurrence and metastasis. The present study aimed to investigate the regulatory mechanisms of glutamate-rich WD-repeat-containing protein 1 (GRWD1) in TNBC cells. The expression of GRWD1 in the normal human breast epithelial cells and human breast cancer cells was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. The transfection effects of small interfering RNA (siRNA)-GRWD1 and overexpression (Ov)-Notch1 were also confirmed by RT-qPCR and western blotting. The proliferation, apoptosis, invasion and migration of transfected cells were in turn analyzed by Cell Counting Kit-8, 5-Ethynyl-2'-deoxyuridine, Matrigel and wound healing assays. The expression of proteins related to proliferation, apoptosis, metastasis, epithelial-mesenchymal transition and the Notch signaling pathway was detected by western blotting. As a result, GRWD1 expression was upregulated in breast cancer cells and was revealed to be highest in MDA-MB-231 and HCC1937 cells. GRWD1 knockdown suppressed TNBC cell proliferation, invasion and migration and promoted TNBC cell apoptosis. Furthermore, the expression of Notch1 and Notch4 was inhibited by GRWD1 knockdown. The expression of downstream genes of the Notch signaling pathway Hes1, Hes5, Hey1, Hey2, p21, c-Myc, cyclin D1, human epidermal growth factor 2 receptor and NF-κB were all suppressed after siRNA-GRWD1 transfection. However, Notch1 overexpression reversed the effect of GRWD1 knockdown on biological behaviors of TNBC cells. In conclusion, GRWD1 knockdown could suppress the proliferation, invasion and migration and promoted apoptosis of TNBC cells through inhibiting the Notch signaling pathway.

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Section: Introductionmentioning

confidence: 99%

GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway

Yao

Tian

2022

Exp Ther Med

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“…Because the vast majority of benign PTs (87%) have areas similar to FA on pathological sections [ 11 ], BPT is easily misdiagnosed as FA and performed with lumpectomy, and the correct diagnosis is not made until the pathological section is reviewed for recurrence after surgery. Moreover, BPT may transform into borderline and even malignant phyllodes tumors after recurrence, and distant metastasis leads to patient death [ 12 ], so there is a need to find new and reliable tumor biomarkers for differentiating BPT from FA.…”

Section: Introductionmentioning

confidence: 99%

miR-140-3p is a potential differential biomarker in benign phyllodes tumors and fibroadenoma of the breast

Liu

Bai

et al. 2022

BMC Women's Health

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Background Benign phyllodes tumor (BPT) and fibroadenoma (FA) have some difficulties in differential diagnosis. BPT is often misdiagnosed as FA during the first operation and is not diagnosed until postoperative recurrence and reoperation. The intent of this research was to find and validate microRNAs (miRNAs) with significant differential expression between BPT and FA as novel potential differential biomarkers. Methods Tissue specimens from three BPT patients and three FA patients were selected to detect the expression of miRNAs by miRNA-Seq technique. Primary cells were extracted and cultured from fresh BPT and FA tissues by tissue-block culture. The expression of differentially expressed miRNA (DEmiRNA) was further verified by quantitative real-time polymerase chain reaction (qRT-PCR) in twelve BPT and eleven FA patient specimens as well as primary cells. Data with a P value < 0.05 were considered statistically significant. Results The miRNA-Seq results showed totally six DEmiRNA were identified, consisting of two downregulated genes and four upregulated genes in BPT. Further validation by qRT-PCR manifest that miR-140-3p was downregulated by approximately 70% in BPT. Conclusion miR-140-3p could become potential differential biomarker for BPT and FA.

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Relapsing malignant phyllodes tumour presenting as isolated acrometastases

Reason,

Aiduk,

Eward

et al. 2024

BMJ Case Rep

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Malignant phyllodes tumours (PTs) are aggressive neoplasms with high rates of local recurrence and distant metastasis. With no known effective chemotherapy and no approved targeted therapy in the setting of metastatic disease, prognosis is limited with an often-relapsing course of disease. We report a case of a woman in her late 30s with a diagnosis of recurrent metastatic malignant PT who was found to have acrometastases of the malignant PT to the right distal index and small digits. We emphasise the potential for atypical patterns of metastases in patients with malignant PT and the need to recognise acrometastasis as an unusual but morbid manifestation of disease. Given the high growth rate of malignant PTs, the lack of systemic treatment options, and the ensuing distress for patients, prompt diagnosis and early intervention is crucial.

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Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review

Cited by 4 publications

References 36 publications

GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway

GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway

miR-140-3p is a potential differential biomarker in benign phyllodes tumors and fibroadenoma of the breast

Relapsing malignant phyllodes tumour presenting as isolated acrometastases

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