Histopathological characterization of ulcerated breast cancer and comparison to their non-ulcerated counterparts

Staudigl, Christine; Bartova, M; Salama, Mohamed; Dzagnidze, Giorgi; Bagó-Horváth, Zsuzsanna; Pohlodek, Kamil; Singer, Christian F.; Tea, Muy‐Kheng M.

doi:10.1007/s13277-014-2977-7

Cited by 4 publications

(9 citation statements)

References 30 publications

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“…Fortunately, this group does not represent most breast cancers (approximately 6% to 15%). In one study evaluating the histopathologic features of ulcerated versus nonulcerated breast cancers, most of the neoplasms were invasive ductal carcinoma (85.5%), and only 9.9% were noninvasive ductal carcinoma 33 . Yet, cancers with much less frequent primary breast neoplasm, such as sarcoma, may present as ulcerated lesions as well, requiring tissue biopsy 34 .…”

Section: Breast Ulcers With An Underlying Massmentioning

confidence: 99%

“…31 Ulcerated breast cancer represents a subgroup of locally advanced breast cancer with an unfavorable tumor stage and poor overall survival. 32,33 Fortunately, this group does not represent most breast cancers (approximately 6% to 15%). In one study evaluating the histopathologic features of ulcerated versus nonulcerated breast cancers, most of the neoplasms were invasive ductal carcinoma (85.5%), and only 9.9% were noninvasive ductal carcinoma.…”

Section: Breast Ulcers With An Underlying Mass Neoplastic Ulcers Of T...mentioning

confidence: 99%

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Get It Off Your Chest: A Narrative Review of Breast Ulcers

Shavit

Alavi

2022

Adv Skin Wound Care

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To provide comprehensive information about breast ulcers to facilitate accurate diagnosis and treatment of these lesions. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant will: 1. Differentiate common wound complications after mastectomy. 2. Identify the clinical manifestations of various types of breast ulcers. 3. Explain appropriate pharmacologic and nonpharmacologic treatment options for various types of breast ulcers.

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Section: Breast Ulcers With An Underlying Massmentioning

confidence: 99%

Section: Breast Ulcers With An Underlying Mass Neoplastic Ulcers Of T...mentioning

confidence: 99%

Get It Off Your Chest: A Narrative Review of Breast Ulcers

Shavit

Alavi

2022

Adv Skin Wound Care

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“…Ulceration caused by skin invasion of malignant tumors is known as a 'malignant wound' [6,7]. Previous reports have indicated that the presence of malignant wounds is associated with poor prognoses in carcinomas [8]. Okajima et al reported that malignant wounds in soft tissue sarcomas were statistically significantly associated with poor prognoses [9].…”

Section: Introductionmentioning

confidence: 99%

Tumor-skin invasion is a reliable risk factor for poor prognosis in superficial soft tissue sarcomas

Iwai¹,

Hoshi²,

Oebisu³

et al. 2022

PLoS ONE

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Introduction Superficial soft tissue sarcomas are often left untreated unless they invade the skin and skin ulcers manifest. Progressive sarcomas frequently result in dismal oncological outcomes despite multidisciplinary treatment. This study aimed to identify prognostic factors for superficial soft tissue sarcomas. Materials and methods This study retrospectively analyzed the clinicopathological data of 82 patients with superficial soft tissue sarcomas treated between August 2003 and December 2020 at our institution. A superficial soft tissue sarcoma was defined if the percentage of the area occupied by the tumor in the assessed region (skin, subcutaneous) was more than 50%. Age, sex, location, tumor size, tumor-skin invasion, tumor grade, and distant metastasis at initial diagnosis were evaluated as potential prognostic factors. Cox proportional hazards regression models were used to identify the prognostic factors. Five-year survival rates were assessed by the Kaplan-Meier method. Results The mean follow-up time was 60.1 months. The 5-year overall survival, 5-year local recurrence-free survival, and 5-year metastasis survival rates were 76.4%, 60.6%, and 71.0%, respectively. Univariate analysis showed significant relationships between poor prognosis and tumor size ≥5 cm, distant metastasis at initial diagnosis, and tumor-skin invasion. In the multivariate analysis, only the tumor-skin invasion was associated with worse overall survival. Conclusions Superficial soft tissue sarcomas have biologically been considered a separate category due to their better prognosis. In this study, the tumor-skin invasion was the only significant factor associated with a poor prognosis. Therefore, all superficial soft tissue sarcomas without tumor-skin invasion should be treated as early as possible.

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“…Ulcerated locally advanced breast carcinoma (LABC) 1,2 is an uncommon topic in the literature. Several factors contribute to delayed diagnosis, such as the health system, factors related to the patient (lack of knowledge, fear and denial of the disease), in addition to rapid tumor growth.…”

mentioning

confidence: 99%

“…They are usually high histologicgrade tumors, high Ki67 index and triple negative breast cancer (TNBC) molecular subtype with lymph node involvement 2 . There are disagreements about the simple presence of ulceration determining worsening of patient's prognosis 1,2 .…”

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confidence: 99%