Why the Platelets were Discovered

Robb‐Smith, A. H. T.

doi:10.1111/j.1365-2141.1967.tb00769.x

Cited by 35 publications

(10 citation statements)

References 14 publications

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“…Lister devised a method of lens combination, by which the aberrations of one lens could be neutralized by a second. With Lister’s microscope it was possible to resolve objects about 1 μm apart (Robb‐Smith, 1967).…”

Section: The Discovery Of Platelets and Their Link With Itpmentioning

confidence: 99%

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ITP: a historical perspective

Stasi

Newland

2011

Br J Haematol

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SummaryA clinical syndrome of bleeding and purpura consistent with a diagnosis of immune thrombocytopenia (ITP) was described by Werlhof long before platelets were identified as the cellular component of blood playing an essential role in primary haemostasis. Although a role for the spleen was suggested nearly a century ago, the pathophysiology of ITP has remained elusive for many decades. During this time Werlhof's disease was renamed idiopathic thrombocytopenic purpura, from which the acronym ITP originally derives. The second half of the 20th century brought recognition of the autoimmune components of ITP, and hence the need for a new standard nomenclature, which has recently been accepted. ITP currently stands for Immune Thrombocytopenia, a name that more appropriately reflects the low platelet count rather than purpura as the main feature of the disease, as well as to defining its underlying nature. Advances in our knowledge of the disease have paralleled the availability of new therapeutic agents, and we are now entering an era of pathophysiologically-based treatment options.

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Section: The Discovery Of Platelets and Their Link With Itpmentioning

confidence: 99%

“…In 1841 two English physicians, George Gulliver (1804–1882) and William Addison (1803–1881), independently made the first drawings of platelets (Robb‐Smith, 1967). However, only Addison associated these platelets with fibrin formation.…”

Section: The Discovery Of Platelets and Their Link With Itpmentioning

confidence: 99%

ITP: a historical perspective

Stasi

Newland

2011

Br J Haematol

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“…Despite of that, platelets are indispensable for processes such as hemostasis, thrombosis, wound healing, angiogenesis, immunity, and inflammation in both health and disease [3–13]. Historically, they were first visualized under a microscope by George Gulliver in the nineteenth century [14]. However, the events that lead to mature platelet production still two centuries later are not completely understood.…”

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confidence: 99%

Lung as a Niche for Hematopoietic Progenitors

Borges

Sena

Azevedo

et al. 2017

Stem Cell Rev and Rep

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Platelets are released from megakaryocytes. The bone marrow has been proposed to be the major site where this process occurs. Lefrançais et al. (2017) using state-of-the-art techniques including two-photon microscopy, in vivo lineage-tracing technologies, and sophisticated lung transplants reveal that the lung is also a primary site for platelet biogenesis. Strikingly, lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia. This study also shows that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs. This work brings a novel unexpected role for the lung as a niche for hematopoiesis. The emerging knowledge from this research may be important for the treatment of several disorders.

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“…11 He was among the first to describe blood platelets and to recognize their contribution to human thrombi. 10,12,13 Osler's landmark textbook, The Principles and Practice of Medicine, first published in 1892, provides a convenient window into the state of hematologic knowledge at that time. The section on diseases of the blood occupies just 24 of 1050 pages and is combined with the section on diseases of the ductless glands in one chapter.…”

Section: Introductionmentioning

confidence: 99%

“…Quantitation of red blood cells (RBCs) was achieved by the development of the hemocytometer and accurate pipettes for diluting blood samples, but reproducibility remained challenging well into the 20th century. 7 The platelet was the last formed element of blood to be quantified because of its size, 13 but by 1910 Duke in Boston was able to demonstrate a compelling correlation between clinical hemorrhage, a low platelet count, and a prolonged bleeding time based on puncturing the earlobe. 27 Moreover, he showed that a whole blood transfusion raised the platelet count and immediately stanched the bleeding.…”

Section: Introductionmentioning

confidence: 99%

Blood at 70: its roots in the history of hematology and its birth

Coller

2015

Blood

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This year we celebrate Blood's 70th year of publication. Created from the partnership of the book publisher Henry M. Stratton and the prominent hematologist Dr William Dameshek of Tufts School of Medicine, Blood has published many papers describing major advances in the science and clinical practice of hematology. Blood's founding antedated that of the American Society of Hematology (ASH) by more than 11 years and Stratton and Dameshek helped galvanize support for the creation of ASH. In this review, I place the birth of Blood in the context of the history of hematology before 1946, emphasizing the American experience from which it emerged, and focusing on research conducted during World War II. I also provide a few milestones along Blood's 70 years of publication, including: the growth in Blood's publications, the evolution of its appearance, the countries of submission of Blood papers, current subscriptions to Blood, and the evolution of topics reported in Blood's papers. The latter provides a snapshot of the evolution of hematology as a scientific and clinical discipline and the introduction of new technology to study blood and bone marrow. Detailed descriptions of the landmark discoveries reported in Blood will appear in later papers celebrating Blood's birthday authored by past Editors-in-Chief.

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Why the Platelets were Discovered

Cited by 35 publications

References 14 publications

ITP: a historical perspective

ITP: a historical perspective

Lung as a Niche for Hematopoietic Progenitors

Blood at 70: its roots in the history of hematology and its birth

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