Lung as a Niche for Hematopoietic Progenitors

Borges, Isabella T.; Sena, Isadora F. G.; Azevedo, Patrick O.; Andreotti, Julia P.; Almeida, Viviani Mendes de; Paiva, Ana; Santos, Gabryella S P; Guerra, Daniel; Prazeres, Pedro H. D. M.; Mesquita, Luiza Lousado; Silva, Luanny Souto de Barros; Leonel, Caroline; Mintz, Akiva; Birbrair, Alexander

doi:10.1007/s12015-017-9747-z

Cited by 60 publications

(38 citation statements)

References 112 publications

(86 reference statements)

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“…However, it remains unclear whether this priming needs direct contact between osteoblasts and neutrophils, or whether it depends on molecules secreted by osteoblasts to the bone marrow milieu or even to the circulation that will induce the formation of SiglecF high –expressing neutrophils. Interestingly, a recent study showed that the lung microenvironment serves as a niche to a subtype of hematopoietic stem cells that produce all hematopoietic lineages, including neutrophils [83,84]. It remains unknown whether the neutrophils produced in the lung are also primed by the bones through osteoblasts-derived molecules present in the circulation, and what percentage of tumor promoting SiglecF high – expressing neutrophils originate from the lung.…”

Section: Perspectives / Future Directionsmentioning

confidence: 99%

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Azevedo

Paiva

Santos

et al. 2018

Cancer Metastasis Rev

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Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecF-expressing neutrophils supply to the tumor microenvironment. Interestingly, SiglecF neutrophil signature was associated with worse lung adenocarcinoma patients outcome. This study identifies novel cellular targets for lung cancer treatment. Here, we summarize and evaluate recent advances in our understanding of lung tumor microenvironment.

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Section: Perspectives / Future Directionsmentioning

confidence: 99%

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Azevedo

Paiva

Santos

et al. 2018

Cancer Metastasis Rev

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“…The decisions of stem cells to continue quiescent, self‐renew, or differentiate are dependent on the interaction of these cells with other cells in their surrounding niches . Recently, multiple cell types have been identified as potential niche‐supporting cells for stem cells in the skin .…”

Section: Schwann Cells Plasticity In the Skinmentioning

confidence: 99%

Role of Schwann cells in cutaneous wound healing

Silva

Leonel

Prazeres

et al. 2018

Wound Repair Regeneration

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Dermal wound healing is the process of repairing and remodeling skin following injury. Delayed or aberrant cutaneous healing poses a challenge for the health care system. The lack of detailed understanding of cellular and molecular mechanisms involved in this process hampers the development of effective targeted treatments. In a recent study, Parfejevs et al.-using state-of-the-art technologies, including in vivo sophisticated Cre/loxP techniques in combination with a mouse model of excisional cutaneous wounding-reveal that Schwann cells induce adult dermal wound healing. Strikingly, genetic ablation of Schwann cells delays wound contraction and closure, decreases myofibroblast formation, and impairs skin re-epithelization after injury. From a drug development perspective, Schwann cells are a new cellular candidate to be activated to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of Schwann cells roles in the skin microenvironment.

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“…Genetically modified mice have been widely applied to study cell types within diverse tissues microenvironments (Borges and others 2017; Lousado and others in press). The ability to delete single genes in specific cell types in adult mice has allowed us to answer specific questions regarding the roles of different cell populations in the regulation of several physiologic and pathologic processes (Andreotti and others 2017).…”

Section: Targeting Pericytesmentioning

confidence: 99%

Pericytes Make Spinal Cord Breathless after Injury

et al. 2017

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Traumatic spinal cord injury is a devastating condition that leads to significant neurological deficits and reduced quality of life. Therapeutic interventions after spinal cord lesions are designed to address multiple aspects of the secondary damage. However, the lack of detailed knowledge about the cellular and molecular changes that occur after spinal cord injury restricts the design of effective treatments. Li and colleagues using a rat model of spinal cord injury and in vivo microscopy reveal that pericytes play a key role in the regulation of capillary tone and blood flow in the spinal cord below the site of the lesion. Strikingly, inhibition of specific proteins expressed by pericytes after spinal cord injury diminished hypoxia and improved motor function and locomotion of the injured rats. This work highlights a novel central cellular population that might be pharmacologically targeted in patients with spinal cord trauma. The emerging knowledge from this research may provide new approaches for the treatment of spinal cord injury.

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Lung as a Niche for Hematopoietic Progenitors

Cited by 60 publications

References 112 publications

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Role of Schwann cells in cutaneous wound healing

Pericytes Make Spinal Cord Breathless after Injury

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