White Ring of the Cornea

Nevins, Robert C.; Elliott, James H.

doi:10.1001/archopht.1969.00990020459006

Cited by 7 publications

(2 citation statements)

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“…The white rings of the cornea were first described by Coats in 1912—the opacity is typically a small ring .5-1.0 mm in diameter below the epithelium or within Bowman's membrane. Although Coats initially believed the rings to be congenital and composed of calcium or lead[75], in 1969, Nevins and Elliot excised a Coat's white ring from a human eye and demonstrated that the ring contained iron deposits[76] and no calcium. Their sections of the white ring stained with Gomori's iron stain and were confirmed by electron probe x-ray microanalysis.…”

Section: Diseases Of the Corneamentioning

confidence: 99%

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Iron homeostasis and eye disease

Loh

Hadziahmetovic

Dunaief

2009

Biochimica et Biophysica Acta (BBA) - General Subjects

110

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Summary Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. Firstly, iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators,.

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Section: Diseases Of the Corneamentioning

confidence: 99%

“…Their sections of the white ring stained with Gomori's iron stain and were confirmed by electron probe x-ray microanalysis. Additionally, it is now widely believed that the ring develops following corneal trauma[76-78]. Lastly, in 1981, Reinach and Baum reported cases of a pigmented line at the base of the corneal [79]…”

Section: Diseases Of the Corneamentioning

confidence: 99%