Cornea and Sclera

Hinzpeter, E. N.; Naumann, G. O. H.

doi:10.1007/978-1-4613-8525-7_7

Cited by 6 publications

(11 citation statements)

References 430 publications

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“…Johnson and colleagues 11 claimed that the epithelial cells, either exclusively or in concert with the keratocytes, may play a fundamental role. However, other authors 1,5 suggest that the keratocytes play the primary role in the pathogenesis of this dystrophy. In this latter case, the changes in the epithelium, basement membrane and Bowman's layer are secondary and eventually lead to microcystic epithelial changes and recurrent erosions.…”

Section: Discussionmentioning

confidence: 95%

“…[1][2][3] Its mode of inheritance is autosomal dominant 1,3-5 with a 100 per cent penetrance, 6 although occasionally there may be a noncontributory family history. 4 Neither the siblings nor the offspring of the patient reported here were available for examination to determine occurrence of the dystrophy in the family.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 The dystrophy originates in the subepithelial and anterior stromal region. 1 Later, it progresses to involve mid-Granular dystrophy of the cornea Collin and Hendicott stromal and posterior stromal layers. 10 As the condition progresses, the lesions become larger, coalesce and increase in number.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, there are sharply circumscribed hyaline (glassy) deposits, primarily in the super ficial stroma 1,2 ( Figure 3) and in the keratocytes. 10 These deposits do not stain positively for mucopolysaccharides or with periodic acid shiff (PAS) stain 1 and they are not constituted of proteoglycans, collagen, calcium or amyloid.…”

Section: Discussionmentioning

confidence: 99%

“…Electron microscopic studies have suggested that there is an intracellular degeneration of keratocytes forming rod-shaped electron dense crystalline deposits in Bowman's layer. 1 The source of the deposits has been a matter of controversy. Johnson and colleagues 11 claimed that the epithelial cells, either exclusively or in concert with the keratocytes, may play a fundamental role.…”

Section: Discussionmentioning

confidence: 99%

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Granular dystrophy of the cornea

Collin

Hendicott

1999

Clinical and Experimental Optometry

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Background: Granular corneal dystrophy is the commonest of the dystrophies and usually results in visual disability in the fourth or fifth decades. Case history: A patient with granular corneal dystrophy is reported and the clinical characteristics described. Discussion: The classical clinical features and the pathology and management of granular dystrophy are reviewed. Two unusual variations of the corneal dystrophy, namely, juvenile granular dystrophy and Avellino dystrophy, which is a concurrence of the features of granular and lattice dystrophies, are also described.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Granular dystrophy of the cornea

Collin

Hendicott

1999

Clinical and Experimental Optometry

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Adoption of Innovation in Herpes Simplex Virus Keratitis

Chodosh

Ung

2020

Cornea

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: Herpes simplex keratitis, caused primarily by human herpes simplex virus type 1 (HSV-1), remains the most common infectious cause of unilateral blindness and vision impairment in the industrialized world. Major advances in the care of HSV keratitis have been driven in large part by the landmark Herpetic Eye Disease Study randomized clinical trials, which were among the first in ophthalmology to reflect emerging trial conventions, including multicenter subject enrollment, double-masking, placebo controls, and a priori sample size determinations. The results of these trials now form much of the evidence basis for the management of this disease. However, management patterns in clinical practice often deviate from evidence-based care. These perceived quality gaps have given rise to the evolving field of implementation science, which is concerned with the methods of promoting the application of evidence-based medicine within routine care. To overcome variations in the quality and consistency of care for HSV keratitis, a range of clinical- and technology-based innovations are proposed. The most pressing needs include the following: a rational and tractable disease classification scheme that provides an immediate link between the anatomical localization of disease (corneal epithelial, stromal, or endothelial) and the appropriate treatment, and the actualization of an electronic medical record system capable of providing evidence-based treatment algorithms at relevant points of care. The latter would also input data to population-wide disease registries to identify implementation-rich targets for quality improvement, education, and research. These innovations may allow us to reduce the human and economic burdens of this highly morbid, and often blinding, disease.

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Morphological evaluation of normal human corneal epithelium

Ehlers¹,

Heegaard

Hjortdal³

et al. 2010

Acta Ophthalmologica

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Acta Ophthalmol. 2010: 88: 858–861 Abstract. Purpose: The human corneal epithelium is usually described as a 50‐μm‐thick layer of regular stratified squamous non‐keratinized cells with a thickness of 5–7 cells. The purpose of this study is systemically to revisit the histopathological appearance of 100 corneas. Methods: 5‐μm‐thick sections of corneas from 100 consecutively selected paraffin‐embedded eyes were stained with hematoxylin–eosin and Periodic Acid‐Schiff (PAS). All specimens were evaluated by light microscopy. The eyes were enucleated from patients with choroidal melanoma. Corneas were considered to be normal. Results: Ninety of 100 eyes were evaluated. The central epithelial, stromal and total corneal thickness was measured as 36.0 μm, 618 μm and 651 μm, respectively, with a variation coefficient from 0.21 to 0.22. Pathological appearances were found in 27% of corneas, including thickened basement membrane and alterations in Bowman’s membrane. No intraepithelial microcysts, as found in Meesmann corneal dystrophy, were observed. Conclusion: The total corneal thickness was higher than reported in in vivo studies and with a wider variation. This may be an effect of uncontrolled swelling and dehydration during preparation. The high number of pathological observations suggests that ‘normal’ eyes harbour and potentially accumulate considerable pathology.

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Cornea and Sclera

Cited by 6 publications

References 430 publications

Granular dystrophy of the cornea

Granular dystrophy of the cornea

Adoption of Innovation in Herpes Simplex Virus Keratitis

Morphological evaluation of normal human corneal epithelium

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