Which Uterotonic Is Better to Prevent the Postpartum Hemorrhage? Latest News in Terms of Clinical Efficacy, Side Effects, and Contraindications: A Systematic Review

Gizzo, Salvatore; Patrelli, Tito Silvio; Gangi, Stefania Di; Carrozzini, Monica; Saccardi, Carlo; Zambon, A.; Bertocco, Anna; Fagherazzi, Simone; D’Antona, Donato; Nardelli, Giovanni Battista

doi:10.1177/1933719112468951

Cited by 69 publications

(48 citation statements)

References 47 publications

(124 reference statements)

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“…Because the current study subjects used Oxytocin (as doctor order) which seems to be the medication of choice to avoid the side effects associated with ergometrine [18]. This fact is supported by Salvatore, et al [19] as they said that prophylactic Oxytocin is the primary choice for PPH prevention. Ergot alkaloids, syntometrine, and prostaglandins are second-line uterotonic substances.…”

Section: Discussionsupporting

confidence: 53%

Effect of Active versus Expectant Nursing Management of Third Stage of Labor on Post-Partum Hemorrhage

Basyouni¹

2017

IOSR JNHS

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Section: Discussionsupporting

confidence: 53%

Effect of Active versus Expectant Nursing Management of Third Stage of Labor on Post-Partum Hemorrhage

Basyouni¹

2017

IOSR JNHS

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“…Methyl ergometrine is another potent uterotonic agent which was used extensively earlier. But it fell into disrepute because of its unpleasant side effects like hypertension and its contraindication in certain cases [11].…”

Section: Discussionmentioning

confidence: 99%

“…At least one risk factor for PPH 16 17 Values indicate the percentage While it is clear that use of prophylactic uterotonics will substantially reduce the bleeding in the third stage of labor and prevents PPH, the most cost-effective and ideal uterotonic has not been elucidated [6,11]. Oxytocin is the most commonly used uterotonic and has been well known in midwifery for a long time [12].…”

Section: Discussionmentioning

confidence: 99%

Carboprost Versus Oxytocin for Active Management of Third Stage of Labor: A Prospective Randomized Control Study

Kumar

Sundar

Batakurki

2016

J Obstet Gynecol India

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Background and Objectives Postpartum hemorrhage is the single largest and leading cause of maternal morbidity and mortality not only in developing countries but also in developed countries. The present study is an attempt to evaluate the scope of using prophylactic intramuscular carboprost tromethamine 125 lg in comparison with intramuscular oxytocin 10 units for the active management of third stage of labor. Materials and Methods Two hundred pregnant women at term with spontaneous onset of labor were included in the study and were randomly divided into 2 groups of 100 women each. Group A and group B were given injection oxytocin 10 units and injection carboprost tromethamine 125 lg intramuscularly, respectively, at the time of delivery of anterior shoulder. The main outcome measures with respect to third stage of labor were: duration, blood loss by volume, difference in hemoglobin, need for additional oxytocics and side effects. Results Subjects who received carboprost tromethamine 125 lg showed a significant reduction in duration of third stage of labor (p \ 0.05) and blood loss (p \ 0.01) when compared to the subjects who received oxytocin 10 units.

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“…Много внимания в последние годы уделялось приме-нению простагландинов (ПГ) для профилактики кровоте-чения после родов [22,23]. Однако ряд объединенных международных исследований показал, что они не имеют преимуществ перед традиционными утеротониками [24,25].…”

Section: ключевые слова: послеродовые кровотечения профилактика лечunclassified

“…Хотя такие инъекцион-ные ПГ, как 15-метил-ПГF 2α , или сульпростон, могут предупредить развитие тяжелого кровотечения при ваги-нальных родах, безопасность и стоимость ограничивают их рутинное применение при активном ведении третьего периода родов. Тем не менее их назначение обоснованно для лечения ПРК в случае неэффективности других вме-шательств [23].…”

Section: ключевые слова: послеродовые кровотечения профилактика лечunclassified

International experience with pabal (carbetocin) for the prevention and treatment of postpartum hemorrhage

Shakurova¹,

Ivshin²,

Yatsukhno³

et al. 2016

Ross. vestn. akush.-ginekol.

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. ShakUrOVa, Cand. Med. Sci.; a.a. iVShiN, Cand. Med. Sci.; l.V. yaTSUkhNO; i.e. yakOVleVa; a.i. yakOVleVa; P.V. kOlyBiNa republican Perinatal Center, republic of karelia, Petrozavodsk, russiaThe given review paper briefly considers traditional medicamentous methods for the prevention and treatment of postpartum hemorrhage. Primary emphasis is placed on the use of the longacting oxytocin agonist carbetocin (pabal) to prevent postpar tum hemorrhage, after abdominal delivery in particular. analysis of published works has established that carbetocin combines the safety and tolerability of oxytocin and the stable uterotonic effect of ergometrine. at present, carbetocin (pabal) is primarily indicated for the prevention of uterine hypotonicity and atony during cesarean section. The single intravenous administration of 100 µg of carbetocin (pabal) versus placebo or intravenous oxytocin significantly reduces the need for additional uterotonics to maintain adequate uterine tone and to prevent/treat massive hemorrhage after cesarean section. The administration of this drug is noted to be associated with a lower rate of adverse effects. Carbetocin (pabal) has great economic advantages over ocytocin.The authors declare no conflicts of interest.

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Which Uterotonic Is Better to Prevent the Postpartum Hemorrhage? Latest News in Terms of Clinical Efficacy, Side Effects, and Contraindications: A Systematic Review

Abstract: Prophylactic oxytocics should be offered routinely in the third stage of labor in all women. The prophylactic use of uterotonics should be individualized.

Cited by 69 publications

References 47 publications

Effect of Active versus Expectant Nursing Management of Third Stage of Labor on Post-Partum Hemorrhage

Effect of Active versus Expectant Nursing Management of Third Stage of Labor on Post-Partum Hemorrhage

Carboprost Versus Oxytocin for Active Management of Third Stage of Labor: A Prospective Randomized Control Study

International experience with pabal (carbetocin) for the prevention and treatment of postpartum hemorrhage

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