International experience with pabal (carbetocin) for the prevention and treatment of postpartum hemorrhage

Abstract

. ShakUrOVa, Cand. Med. Sci.; a.a. iVShiN, Cand. Med. Sci.; l.V. yaTSUkhNO; i.e. yakOVleVa; a.i. yakOVleVa; P.V. kOlyBiNa republican Perinatal Center, republic of karelia, Petrozavodsk, russiaThe given review paper briefly considers traditional medicamentous methods for the prevention and treatment of postpartum hemorrhage. Primary emphasis is placed on the use of the longacting oxytocin agonist carbetocin (pabal) to prevent postpar tum hemorrhage, after abdominal delivery in particular. analysis of published works has established that carbetocin combines the safety and tolerability of oxytocin and the stable uterotonic effect of ergometrine. at present, carbetocin (pabal) is primarily indicated for the prevention of uterine hypotonicity and atony during cesarean section. The single intravenous administration of 100 µg of carbetocin (pabal) versus placebo or intravenous oxytocin significantly reduces the need for additional uterotonics to maintain adequate uterine tone and to prevent/treat massive hemorrhage after cesarean section. The administration of this drug is noted to be associated with a lower rate of adverse effects. Carbetocin (pabal) has great economic advantages over ocytocin.The authors declare no conflicts of interest.

Uterotonic Drugs in the Prevention of Postpartum Hemorrhages

“…Ряд авторов отмечают роль карбетоцина в снижении артериального давления, что благоприятно влияет на комплексную терапию пациенток с послеродовой преэклампсией [10][11][12].…”

“…Some authors have noted the function of carbetocin to lower blood pressure having a positive effect on the complex therapy of patients with postpartum pre-eclampsia [10][11][12].…”