Wearable electrochemical sensors for forensic and clinical applications

Ferreira, Patrick Cesar; Ataide, Vanessa N.; Chagas, Cyro L. S.; Angnes, Lúcio; Coltro, Wendell K. T.; Paixão, Thiago R.L.C.; Araújo, Wanderley Pereira de

doi:10.1016/j.trac.2019.115622

Cited by 125 publications

(65 citation statements)

References 100 publications

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“…In particular, wearable sensors evidently present a promising and exciting tool for drug detection as the entire process is executed automatically, continuously, and non-invasively or is at least minimally invasive. Previously, wearable sensors have also been used in point-of-care and in situ detection of suspected toxicity or drug abuse via sensing at the fingertips in a wearable glove [ [97] , [98] , [99] ]. In contrast, E-AB sensors are being proven as a universal approach by which an arbitrary molecular analyte can be monitored continuously.…”

Section: Discussionmentioning

confidence: 99%

Towards wearable and implantable continuous drug monitoring: A review

Bian

Zhu

Rong

et al. 2021

Journal of Pharmaceutical Analysis

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Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has strong potential to reshape our understanding of pharmacokinetic variability and to improve individualised therapy. This review highlights recent advances in biosensing technologies that support continuous drug monitoring in real time. We focus primarily on aptamer-based biosensors, wearable and implantable devices. Emphasis is given to the approaches employed in constructing biosensors. We pay attention to sensors’ biocompatibility, calibration performance, long-term characteristics stability and measurement quality. In the end, we discuss about the current challenges and issues to address in continuous drug monitoring to make it a promising, future tool for individualised therapy. The ongoing efforts are expected to result in fully integrated implantable drug biosensing technology. Thus, we may anticipate an era of advanced healthcare in which wearable and implantable biochips automatically adjust drug dosing in response to patient health conditions enabling the management of diseases and enhancing individualised therapy.

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Section: Discussionmentioning

confidence: 99%

Towards wearable and implantable continuous drug monitoring: A review

Bian

Zhu

Rong

et al. 2021

Journal of Pharmaceutical Analysis

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“…Nanomaterials have been utilized and demonstrated in wearable, portable, and miniaturized electrochemical sensors for many applications, ranging from quick diagnostic tools to modern healthcare and biomedical applications [17][18][19][20]. These open up exciting opportunities to realize immediate or continuous analytical detection of significant biomarkers or pathogens for out-of-clinic biomedical evaluation.…”

Section: Conclusion and Outlooksmentioning

confidence: 99%

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

2020

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Personal biosensors and bioelectronics have been demonstrated for use in out-of-clinic biomedical devices. Such modern devices have the potential to transform traditional clinical analysis into a new approach, allowing patients or users to screen their own health or warning of diseases. Researchers aim to explore the opportunities of easy-to-wear and easy-to-carry sensors that would empower users to detect biomarkers, electrolytes, or pathogens at home in a rapid and easy way. This mobility would open the door for early diagnosis and personalized healthcare management to a wide audience. In this review, we focus on the recent progress made in modern electrochemical sensors, which holds promising potential to support point-of-care technologies. Key original research articles covered in this review are mainly experimental reports published from 2018 to 2020. Strategies for the detection of metabolites, ions, and viruses are updated in this article. The relevant challenges and opportunities of applying nanomaterials to support the fabrication of new electrochemical biosensors are also discussed. Finally, perspectives regarding potential benefits and current challenges of the technology are included. The growing area of personal biosensors is expected to push their application closer to a new phase of biomedical advancement.

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“…[77][78][79][80][81] Os eletrodos impressos (EI), esquematizado na Figura 7, além de atender a esses pré-requisitos, permitem a automação na fabricação, por conterem os eletrodos de trabalho, auxiliar e de referência em um mesmo suporte. [82][83][84][85][86] As aplicações podem se estender a diferentes tipos de modificadores, 87 como por exemplo, eletrodos impressos em tela para controle de qualidade de combustíveis líquidos 88 e análises clínicas. 89 As diversas técnicas para a produção dos eletrodos impressos, levam a diferentes geometrias/configurações e composição do material, dentre essas técnicas de produção estão o microcontato, 90,91 a litografia, 92 a impressão por jato de tinta e a serigrafia.…”

Section: Eletrodos Impressos E "Laboratório Em Um úNico Chip" (Lab-onunclassified

Electrochemistry: Modified Electrodes and their Potentialities

Monteiro¹,

Júnior²,

Sussuchi³

2020

Rev. Virtual Quim.

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Electrochemical sensors are analytical tools that offer great portability, ease automation, miniaturization capability, and low cost compared to other analytical techniques and methods. For those reasons, there is a growing search for these electrodes to obtain better analysis conditions. This advance is reflected in new patents and articles, which were intensified mainly with the arising of chemically modified electrodes and self-sufficient equipment. Besides, this study brings together and discusses the main aspects of electrochemical methods, the development of electrodes and their modifiers, as well as the perspectives for these electroanalytical tools. Os sensores eletroquímicos são ferramentas de análise que oferecem maior portabilidade, facilidade de automação, capacidade de miniaturização e baixo custo em relação a outras técnicas e métodos analíticos. Por essas razões, existe uma crescente busca pelo desenvolvimento desses eletrodos a fim de se obter melhores condições de análise. Esse avanço reflete em novas patentes e artigos que se intensificaram, principalmente com o surgimento dos eletrodos quimicamente modificados e equipamentos autossuficientes. Em suma, esse estudo reúne e discute aspectos fundamentais concernentes aos métodos eletroquímicos, o avanço no desenvolvimento dos eletrodos e seus modificantes, além das perspectivas para essas ferramentas eletroanalíticas.

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Wearable electrochemical sensors for forensic and clinical applications

Cited by 125 publications

References 100 publications

Towards wearable and implantable continuous drug monitoring: A review

Towards wearable and implantable continuous drug monitoring: A review

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

Electrochemistry: Modified Electrodes and their Potentialities

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