Abstract:Daunorubicin (DAU) is one of the anticancer drugs widely applied in therapy although it reveals high toxicity. As a result of the search for new derivatives of anthracyclines with better biological properties, amidino antracyclines were invented. They contain in the daunosamine moiety an amidine group, –N=CR–NR1R2 where −NR1R2 is the rest of the cyclic secondary amine, instead of the −NH2 group. DAU and its two formamidino derivatives, the one containing the rest of the morpholine in the formamidine group (DAU… Show more
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