Differences in electrochemical response of prospective anticancer drugs IPBD and Cl-IPBD, doxorubicin and Vitamin C at plasmid modified glassy carbon

Janiszek, Dominika; Karpińska, Monika; Niewiadomy, Andrzej; Kośmider, Anita; Girstun, Agnieszka; Elżanowska, H.; Kulesza, Paweł J.

doi:10.1016/j.bioelechem.2020.107682

Cited by 3 publications

(2 citation statements)

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“…Janiszek et al [ 48 ] in their experiment compared two prospective anticancer drugs, 6-(1 H -imidazo [4,5-b]phenasine-2-yl)benzene-1,3-diol (IPBD) and its -Cl derivative (Cl-IPBD) with doxorubicin, a widely used anthracycline anticancer agent. For the comparison of the DNA interactions with the drugs, plasmid modified GCEs were used.…”

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

“…The stationary working electrode is composed of various types of electrode materials. The most common are glassy carbon electrodes (GCEs) [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ], pencil graphite electrodes (PGEs) [ 50 , 51 , 52 , 53 , 54 , 55 , 56 ], carbon paste electrodes (CPEs) [ 57 , 58 ], hanging mercury drop electrodes (HMDEs) [ 59 ], platinum electrodes [ 60 ], and gold electrodes [ 61 , 62 ]. These electrodes can be used either in the bare form [ 44 , 54 , 63 ] or modified with a layer capable of increasing their sensitivity [ 50 , 51 , 52 , 53 , 55 , 56 ].…”

Section: Electrochemical Approach To Dna–drug Interaction Descriptionmentioning

confidence: 99%

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What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

2021

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The interactions of compounds with DNA have been studied since the recognition of the role of nucleic acid in organisms. The design of molecules which specifically interact with DNA sequences allows for the control of the gene expression. Determining the type and strength of such interaction is an indispensable element of pharmaceutical studies. Cognition of the therapeutic action mechanisms is particularly important for designing new drugs. Owing to their sensitivity, simplicity, and low costs, electrochemical methods are increasingly used for this type of research. Compared to other techniques, they require a small number of samples and are characterized by a high reliability. These methods can provide information about the type of interaction and the binding strength, as well as the damage caused by biologically active molecules targeting the cellular DNA. This review paper summarizes the various electrochemical approaches used for the study of the interactions between pharmaceuticals and DNA. The main focus is on the papers from the last decade, with particular attention on the voltammetric techniques. The most preferred experimental approaches, the electrode materials and the new methods of modification are presented. The data on the detection ranges, the binding modes and the binding constant values of pharmaceuticals are summarized. Both the importance of the presented research and the importance of future prospects are discussed.

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Section: Electrochemical Methods Appliedmentioning

confidence: 99%