Carbon quantum dot modified electrodes developed for electrochemical monitoring of Daunorubicin-DNA interaction

Ekşin, Ece; Senturk, Huseyin; Zor, Erhan; Bingöl, Haluk; Erdem, Arzum

doi:10.1016/j.jelechem.2020.114011

Cited by 21 publications

(17 citation statements)

References 50 publications

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“…In voltammetric techniques, the measured electrochemical signal is an algebraic sum of the undesirable capacitive current and the desired current related to the proper electrode reaction, the so-called Faraday current. DPV is an electrochemical technique which is widely used in chemical analysis and for studying the interactions of pharmaceuticals with DNA [ 41 , 43 , 45 , 51 , 60 , 63 , 65 , 94 , 95 ]. Its high sensitivity results from the pulsating change of potential applied to the working electrode.…”

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

“…Such systems have several main advantages: a large surface area, effective mass transport, controllability, and their ability to study interactions in solution. Eksin et al [ 51 ] studied the interaction between daunorubicin (DNR) and ctDNA at the surface of disposable carbon quantum dot-modified PGEs (cQD-PGE). For monitoring the surface-confined interaction, ctDNA was first immobilized onto the electrode surface, and then the electrochemical detection of the interaction between DNA and DNR was carried out.…”

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

“…Other electrochemical methods, including square wave voltammetry (SWV) [ 59 ] and electrochemical impedance spectroscopy (EIS) [ 51 , 90 ], are also used to monitor the binding of molecules to the DNA chain. The first one is a type of linear potential sweep voltammetry involving a combined square wave and a staircase potential applied to a stationary electrode.…”

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

“…Eksin et al [ 51 ] used EIS to investigate the surface-confined interaction of DNR with ctDNA. Nyquist diagrams were recorded before and after the interaction process at different intervals.…”

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

“…The stationary working electrode is composed of various types of electrode materials. The most common are glassy carbon electrodes (GCEs) [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ], pencil graphite electrodes (PGEs) [ 50 , 51 , 52 , 53 , 54 , 55 , 56 ], carbon paste electrodes (CPEs) [ 57 , 58 ], hanging mercury drop electrodes (HMDEs) [ 59 ], platinum electrodes [ 60 ], and gold electrodes [ 61 , 62 ]. These electrodes can be used either in the bare form [ 44 , 54 , 63 ] or modified with a layer capable of increasing their sensitivity [ 50 , 51 , 52 , 53 , 55 , 56 ].…”

Section: Electrochemical Approach To Dna–drug Interaction Descriptionmentioning

confidence: 99%

See 4 more Smart Citations

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

2021

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The interactions of compounds with DNA have been studied since the recognition of the role of nucleic acid in organisms. The design of molecules which specifically interact with DNA sequences allows for the control of the gene expression. Determining the type and strength of such interaction is an indispensable element of pharmaceutical studies. Cognition of the therapeutic action mechanisms is particularly important for designing new drugs. Owing to their sensitivity, simplicity, and low costs, electrochemical methods are increasingly used for this type of research. Compared to other techniques, they require a small number of samples and are characterized by a high reliability. These methods can provide information about the type of interaction and the binding strength, as well as the damage caused by biologically active molecules targeting the cellular DNA. This review paper summarizes the various electrochemical approaches used for the study of the interactions between pharmaceuticals and DNA. The main focus is on the papers from the last decade, with particular attention on the voltammetric techniques. The most preferred experimental approaches, the electrode materials and the new methods of modification are presented. The data on the detection ranges, the binding modes and the binding constant values of pharmaceuticals are summarized. Both the importance of the presented research and the importance of future prospects are discussed.

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Section: Electrochemical Methods Appliedmentioning

confidence: 99%

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

Section: Electrochemical Methods Appliedmentioning

confidence: 99%

Section: Electrochemical Approach To Dna–drug Interaction Descriptionmentioning

confidence: 99%

See 3 more Smart Citations

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

2021

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Carbon Nanodots-Based Electrodes in Biomolecular Screening and Analysis

Dharuman

2023

Handbook of Nanobioelectrochemistry

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Electroanalytical overview: utilising micro- and nano-dimensional sized materials in electrochemical-based biosensing platforms

Crapnell

Banks

2021

Microchim Acta

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Research into electrochemical biosensors represents a significant portion of the large interdisciplinary field of biosensing. The drive to develop reliable, sensitive, and selective biosensing platforms for key environmental and medical biomarkers is ever expanding due to the current climate. This push for the detection of vital biomarkers at lower concentrations, with increased reliability, has necessitated the utilisation of micro- and nano-dimensional materials. There is a wide variety of nanomaterials available for exploration, all having unique sets of properties that help to enhance the performance of biosensors. In recent years, a large portion of research has focussed on combining these different materials to utilise the different properties in one sensor platform. This research has allowed biosensors to reach new levels of sensitivity, but we note that there is room for improvement in the reporting of this field. Numerous examples are published that report improvements in the biosensor performance through the mixing of multiple materials, but there is little discussion presented on why each nanomaterial is chosen and whether they synergise well together to warrant the inherent increase in production time and cost. Research into micro-nano materials is vital for the continued development of improved biosensing platforms, and further exploration into understanding their individual and synergistic properties will continue to push the area forward. It will continue to provide solutions for the global sensing requirements through the development of novel materials with beneficial properties, improved incorporation strategies for the materials, the combination of synergetic materials, and the reduction in cost of production of these nanomaterials. Graphical abstract

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Carbon quantum dot modified electrodes developed for electrochemical monitoring of Daunorubicin-DNA interaction

Cited by 21 publications

References 50 publications

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

Carbon Nanodots-Based Electrodes in Biomolecular Screening and Analysis

Electroanalytical overview: utilising micro- and nano-dimensional sized materials in electrochemical-based biosensing platforms

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