Vogt-Koyanagi-Harada syndrome: A novel case and brief review of focal neurologic presentations

Yoo

2015

Nucl Med Mol Imaging

Vogt-Koyanagi-Harada disease is a rare multisystemic granulomatous autoimmune disorder affecting pigmented tissues such as the choroid, meninges, inner ear, and the skin. Neurologic symptoms are usually mild. Clinical manifestations include generalized muscle weakness, headache, meningismus, vertigo, decreased visual acuity, hearing loss and mental changes ranging from mild confusion to psychosis, hemiparesis, dysarthria, and aphasia. Seizures are very rare. We describe a case of F-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) and software-fused PET-magnetic resonance imaging (MRI) in Vogt-Koyanagi-Harada disease with seizure.

Section: Compliance With Ethical Standardsmentioning

confidence: 99%

F-18 FDG PET Findings for Vogt-Koyanagi-Harada Disease

Yoo

2015

Nucl Med Mol Imaging

“…They described that the leptomeningeal enhancement in VKH may be a marker of early CNS involvement. 3 Pachymeningeal enhancement was reported by Han et al, 4 and Sheriff et al 7 also described dural thickening and cerebellopontine angle mass in addition to the pachymeningeal enhancement. 8 These findings suggest that melanocyte-rich organs were affected by VKH, although several studies have also reported parenchymal brain lesions.…”

Section: Discussionmentioning

confidence: 82%

“… 8 These findings suggest that melanocyte-rich organs were affected by VKH, although several studies have also reported parenchymal brain lesions. 7 , 9 …”

Section: Discussionmentioning

confidence: 99%

Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease

Hida¹,

Takano²,

Yoshimitsu³

et al. 2017

BJR|case reports

Vogt–Koyanagi–Harada (VKH) disease is an autoimmune disorder that occurs in the melanocytes present in the uvea, leptomeninges, skin and inner ear. Clinically, this disease is characterized by bilateral uveitis and retinal detachment and is associated with meningismus and hearing loss. Gadolinium (Gd)-enhanced MRI may aid in demonstrating bilateral choroidal thickening and central nervous system involvement. We present a case of VKH where Gd-enhanced three-dimensional (3D) fluid attenuation inversion recovery (FLAIR) imaging showed abnormal bilateral enhancement in the inner ears. A 36-year-old female was referred to our institution with symptoms of visual disturbance, headache and tinnitus, and was diagnosed with VKH based on fundus examination and clinical presentations. MRI findings revealed bilateral enhancement in the choroid, leptomeninges, and inner ears. In particular, Gd-enhanced 3D FLAIR showed more conspicuous enhancement of the leptomeninges and inner ear compared with Gd-enhanced 3D T1 weighted image. Therefore, Gd-enhanced 3D FLAIR imaging can be used when leptomeningeal or inner ear pathology is clinically suspected.

“…Reported brain imaging findings associated with VKHD include scattered periventricular white matter lesions as well as brain stem and peduncular lesions. Pachymeningeal enhancement is more common in the context of VKHD; however, leptomeningeal enhancement is also encountered [1,5]. In addition, MRI can show the abnormal enhancement of the membranous labyrinth bilaterally.…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease: A Case Report With Distinct Brain MRI Enhancement Patterns

Beltagi

Abdelhady

Barakat

et al. 2020

Cureus

Vogt-Koyanagi-Harada disease is a rare autoimmune granulomatous panuveitis with significant associated morbidity. While ocular and meningeal signs are typically observed in the acute stage, the associated classic tegumentary findings are observed subsequently. This case report highlights the imaging findings associated with this entity that serves to emphasize the role of contrast-enhanced brain MRI in early disease detection, which allows for prompt treatment initiation and better disease outcome.