Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease

Hida, Kazutoshi; Takano, Koichi; Yoshimitsu, Kengo; Fukae, Jiro; Hokao, Koichi

doi:10.1259/bjrcr.20160090

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…An upward-sloping curve may not always be an indicator of Meniere's disease; there were patients suffering from immune-mediated sudden HL who were diagnosed with upsloping audiogram [Campbell and Klemens, 2000;Choi et al, 2011;Rossini et al, 2017]. In our study, the diagnosis of AIHL was mainly based on clinical and immunological laboratory findings; despite our poor MRI results, there is evidence of inner ear enhancement on gadolinium at 3D FLAIR or/and T1 sequences in patients with autoimmune disorders [Ziu and Ajvazi, 2010;Hida et al, 2016], indicating a perilymphatic space inflammation, such as in labyrinthitis [Hwang and Zuccoli, 2015].…”

Section: Discussionmentioning

confidence: 74%

Audiological Patterns in Patients with Autoimmune Hearing Loss

et al. 2021

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Introduction: The aim of this study was to illustrate clinical and audiological patterns of hearing impairment in patients with autoimmune hearing loss (AIHL). Methods: Fifty-three patients with AIHL were retrospectively recruited, and a tapering schema of steroid treatment was administered in all these patients. The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden (sensorineural hearing loss [SSHL]), fluctuating, or quickly progressing (<12 months) SSHL (uni-/bilateral), in association with the coexistence of autoimmune diseases, high antinuclear antibodies (ANA) and the presence of human leukocyte antigen (HLA) B27, B35, B51, C04, and C07. Logistic regression analysis was applied to correlate the clinical data and laboratory features of AIHL with final outcomes. Results: The onset of AIHL was mainly progressive (49%), followed by SSHL (39.6%) or fluctuating (11.3%). The pure-tone audiogram showed more commonly a downsloping pattern (42.6% of ears), but also an upsloping, flat, cookie-bite, or inverse cookie-bite shape. Bilateral progressive AIHL was more frequently simultaneous (23 patients) than heterochronous (4 patients). Nineteen patients (35.8%) showed a favorable response to steroid therapy. The presence of recurrent, bilateral SSHL versus recurrent, unilateral SSHL had statistically negative effect on hearing recovery (OR = 0.042, p < 0.05). The heterochronous bilateral SSHL may have better prognosis than simultaneous bilateral SSHL (OR = 10.000, p = 0.099). The gender, age, concomitant autoimmune disease, high ANA, HLA alleles, tinnitus, and vestibular symptoms had no statistical effect on a favorable outcome of AIHL. Conclusions: A bilateral, simultaneous, and progressive hearing loss combined with downsloping audiogram occurred more often in patients with AIHL. Bilateral simultaneous SSHL with recurrences represents the worse prognostic form of AIHL.

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Section: Discussionmentioning

confidence: 74%

Audiological Patterns in Patients with Autoimmune Hearing Loss

et al. 2021

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“…This is more common at the age of 30-70. 77 Proteomic analyses in blood have recently shown increased expression of some protein biomarkers such as complement factors H and B, and reduction of the plasma beta-2-glycoprotein and vitamin D binding protein. 78 There is no definitive test for diagnosis.…”

Section: Meniere's Diseasementioning

confidence: 99%

Autoimmune disease of head and neck, imaging, and clinical review

et al. 2022

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Autoimmune disease of the head and neck (H&N) could be primary or secondary to systemic diseases, medications, or malignancies. Immune-mediated diseases of the H&N are not common in daily practice of radiologists; the diagnosis is frequently delayed because of the non-specific initial presentation and lack of familiarity with some of the specific imaging and clinical features. In this review, we aim to provide a practical diagnostic approach based on the specific radiological findings for each disease. We hope that our review will help radiologists expand their understanding of the spectrum of the discussed disease entities, help them narrow the differential diagnosis, and avoid unnecessary tissue biopsy when appropriate based on the specific clinical scenarios.

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“…13 3D-FLAIR MRI evaluates the vestibular function and cochlear function relatively more objectively compared with the traditionally used cochlear electrogram. 14 Previous studies have shown that 3D-FLAIR MRI manifestations are correlated with the clinical features and prognosis of ISSNHL patients. The classification of ISSNHL patients through 3D-FLAIR MRI has a potentially important role in the diagnosis and treatment of ISSNHL.…”

Section: ■ Introductionmentioning

confidence: 97%

“…Three-dimensional fluid-attenuated inversion recovery sequence magnetic resonance imaging (3D-FLAIR MRI) has been widely used in the diagnosis of inner ear diseases. , 3D-FLAIR MRI can distinguish between the inner and outer lymphatic spaces of the inner ear of patients, thereby enhancing the understanding of clinicians about the endolymph function of patients . 3D-FLAIR MRI evaluates the vestibular function and cochlear function relatively more objectively compared with the traditionally used cochlear electrogram . Previous studies have shown that 3D-FLAIR MRI manifestations are correlated with the clinical features and prognosis of ISSNHL patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical Value of 3D-FLAIR MRI in Idiopathic Sudden Sensorineural Hearing Loss

Wang

Hu²,

Wang

et al. 2021

ACS Chem. Neurosci.

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Background: Three-dimensional fluid-attenuated inversion recovery sequence magnetic resonance imaging (3D-FLAIR MRI) has been used in the diagnosis of inner ear diseases. However, the relevance of 3D-FLAIR MRI appearances with multiple features and prognosis of patients with idiopathic sudden sensorineural hearing loss (ISSNHL) remains unclear. Methods: This study was a retrospective trial. We recruited 1300 patients with unilateral ISSNHL hospitalized from May 2017 to January 2019. They were divided into four groups according to their 3D-FLAIR MRI appearances: normal (n = 739), inner ear hemorrhage (n = 218), increased protein content (n = 288), and blood–labyrinth barrier damage (n = 55). The correlation between 3D-FLAIR MRI appearances and the degree or type of deafness of the participants was analyzed. Results: There was a statistical difference in the deafness side (p < 0.001) and vestibular dysfunction (p < 0.001) among the four groups. There was a statistical difference in the duration of treatment (p < 0.001) and the incidence of dizziness or vertigo (p < 0.001) for patients among these groups. The degree of deafness in the patients in the inner ear hemorrhage group was significantly more severe than that of the patients in the other three groups (p < 0.001). Conclusion: 3D-FLAIR MRI appearances were correlated with the prognosis of patients with ISSNHL.

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Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease

Cited by 6 publications

References 15 publications

Audiological Patterns in Patients with Autoimmune Hearing Loss

Audiological Patterns in Patients with Autoimmune Hearing Loss

Autoimmune disease of head and neck, imaging, and clinical review

Clinical Value of 3D-FLAIR MRI in Idiopathic Sudden Sensorineural Hearing Loss

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