F-18 FDG PET Findings for Vogt-Koyanagi-Harada Disease

Abstract

Vogt-Koyanagi-Harada disease is a rare multisystemic granulomatous autoimmune disorder affecting pigmented tissues such as the choroid, meninges, inner ear, and the skin. Neurologic symptoms are usually mild. Clinical manifestations include generalized muscle weakness, headache, meningismus, vertigo, decreased visual acuity, hearing loss and mental changes ranging from mild confusion to psychosis, hemiparesis, dysarthria, and aphasia. Seizures are very rare. We describe a case of F-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) and software-fused PET-magnetic resonance imaging (MRI) in Vogt-Koyanagi-Harada disease with seizure.

Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease

“…Park et al have reported a case that 47-year-old man was diagnosed of VKH syndrome with brain involvement via PET/MRI, revealing multifocal FDG uptake areas along the cerebral sulci that is compatible with clinical seizure symptoms. [ 19 ] Compared to the previous report, [ 19 ] there was no tracer uptake area in the brain for our patient, yet, a thyroid lesion was found. The diagnosis of AITD was eventually made due to the lack of malignant tumor markers from the tissue biopsy, and elevated TPO-Ab/Tg-Ab titers in the serological test.…”