Vitamin metal–organic framework-laden microfibers from microfluidics for wound healing

123

This study uses metal–organic frameworks (MOFs) alone without any added antibacterial ingredients as the nonantibiotic agent for photodynamic therapy (PDT) of chronic wounds infected by multidrug‐resistant (MDR) bacteria. Nanoparticles (NPs) of MOFs (PCN‐224) are incorporated with titanium through a facile cation exchange strategy. The obtained bimetallic PCN‐224(Zr/Ti) shows greatly enhanced photocatalytic performance for the generation of reactive oxygen species under visible light, which is responsible for the effective antibacterial activities. The PCN‐224(Zr/Ti) NPs are loaded onto lactic‐co‐glycolic acid nanofibers to prepare a wound dressing, which shows high biocompatibility and minimal cytotoxicity. The wound dressing is efficient for PDT‐based in vivo healing of the chronic wound infected by MDR bacteria. Most importantly, this work does not involve any additional antibacterial agents, which is facile, low cost, and in particular, greatly explores the potential of MOFs as a powerful nonantibiotic agent in PDT.

Section: Methodsmentioning

confidence: 87%

Titanium Incorporation into Zr‐Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug‐Resistant Pathogens

Chen

Zhang

Dong

et al. 2020

123

“…d) Schematic illustration of the formation of the vitamin MOF‐laden fibers by using a microfluidic spinning approach and the application of the fibers in the wound healing process. Reproduced with permission . Copyright 2018, Royal Society of Chemistry.…”

Section: Microfluidic Spinning Of Nfsmentioning

confidence: 98%

“…In addition, anti‐infective agents or growth factors can be encapsulated into these fibers, which further reinforce the repairing ability of these dressings . Yu et al generated copper‐ or zinc‐MOF laden alginate fibers using a double co‐axial microfluidic device for wound healing (Figure d) . The composition, size and morphology of the hybrid fibers could be tuned by simply adjusting the flow rates, which determined the release kinetics of the encapsulated MOF.…”

Section: Microfluidic Spinning Of Nfsmentioning

confidence: 99%

Microfluidic Generation of Nanomaterials for Biomedical Applications

Zhao

Bian

Sun

et al. 2019

Self Cite

As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over the reaction conditions, not only can NMs with high quality and rapid production rate be generated, but also designing composite and efficient products for therapy and diagnosis in nanomedicine can be realized. Recent evidence implies that microfluidic technology offers a promising platform for the synthesis of NMs by easy manipulation of fluids in microscale channels. In this Review, a comprehensive set of developments in the field of microfluidics for generating two main classes of NMs, including nanoparticles and nanofibers, and their various potentials in biomedical applications are summarized. Furthermore, the major challenges in this area and opinions on its future developments are proposed.

“…Not only particulate materials, but also hydrogel microfibers enabling encapsulation and controlled release of drugs such as antibacterial metal‐organic frameworks (MOFs) can be formed by multiphase microfluidics. The hydrogel microfibrous scaffolds with locally controlled releasing MOFs have shown their superior performance in assisting wound healing (Figure d) . Furthermore, in addition to producing DDSs, the capabilities of microfluidics in formulating different drugs that meet U.S. Pharmacopeia standards have been also demonstrated .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…d) Microfibrous hydrogel scaffolds with locally controlled releasing antibacterial MOFs for promoting wound healing. Reproduced with permission . Copyright 2018, the Royal Society of Chemistry (RSC).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Microfluidic Platforms toward Rational Material Fabrication for Biomedical Applications

Zhao

Cui

Wang

et al. 2019

The emergence of micro/nanomaterials in recent decades has brought promising alternative approaches in various biomedicine‐related fields such as pharmaceutics, diagnostics, and therapeutics. These micro/nanomaterials for specific biomedical applications shall possess tailored properties and functionalities that are closely correlated to their geometries, structures, and compositions, therefore placing extremely high demands for manufacturing techniques. Owing to the superior capabilities in manipulating fluids and droplets at microscale, microfluidics has offered robust and versatile platform technologies enabling rational design and fabrication of micro/nanomaterials with precisely controlled geometries, structures and compositions in high throughput manners, making them excellent candidates for a variety of biomedical applications. This review briefly summarizes the progress of microfluidics in the fabrication of various micro/nanomaterials ranging from 0D (particles), 1D (fibers) to 2D/3D (film and bulk materials) materials with controllable geometries, structures, and compositions. The applications of these microfluidic‐based materials in the fields of diagnostics, drug delivery, organs‐on‐chips, tissue engineering, and stimuli‐responsive biodevices are introduced. Finally, an outlook is discussed on the future direction of microfluidic platforms for generating materials with superior properties and on‐demand functionalities. The integration of new materials and techniques with microfluidics will pave new avenues for preparing advanced micro/nanomaterials with enhanced performance for biomedical applications.