Current strategies for wound care provide limited relief to millions of patients who suffer from burns, chronic skin ulcers or surgical-related wounds. The goal of this work is to develop an in situ deposition of a personalized nanofibrous dressing via a handy electrospinning (e-spinning) device and evaluate its properties related to skin wound care. MCM-41 type mesoporous silica nanoparticles decorated with silver nanoparticles (Ag-MSNs) were prepared by a facile and environmentally friendly approach, which possessed long-term antibacterial activity and low cytotoxicity. Poly-ε-caprolactone (PCL) incorporated with Ag-MSNs was successfully electrospun (e-spun) into nanofibrous membranes. These in situ e-spun nanofibrous membranes allowed the continuous release of Ag ions and showed broad-spectrum antimicrobial activity against two common types of pathogens, Staphylococcus aureus and Escherichia coli. In addition, the in vivo studies revealed that these antibacterial nanofibrous membranes could reduce the inflammatory response and accelerate wound healing in Wistar rats. The above results strongly demonstrate that such patient-specific dressings could be broadly applied in emergency medical transport, hospitals, clinics and at the patients' home in the near future.

Electrospinning (e-spinning) has been extensively explored as a simple, versatile, and cost-effective method in preparing ultrathin fibers from a wide variety of materials. Electrospun (e-spun) ultrathin fibers are now widely used in tissue scaffold, wound dressing, energy harvesting and storage, environment engineering, catalyst, and textile. However, compared with conventional fiber industry, one major challenge associated with e-spinning technology is its production rate. Over the last decade, compared with conventional needle e-spinning, needleless e-spinning has emerged as the most efficient strategy for large-scale production of ultrathin fibers. For example, rolling cylinder and stationary wire as spinnerets have been commercialized successfully for significantly improving throughput of e-spun fibers. The significant advancements in needleless e-spinning approaches, including spinneret structures, productivity, and fiber quality are reviewed. In addition, some striking examples of innovative device designs toward higher throughput, as well as available industrial-scale equipment and commercial applications in the market are highlighted.

This study uses metal–organic frameworks (MOFs) alone without any added antibacterial ingredients as the nonantibiotic agent for photodynamic therapy (PDT) of chronic wounds infected by multidrug‐resistant (MDR) bacteria. Nanoparticles (NPs) of MOFs (PCN‐224) are incorporated with titanium through a facile cation exchange strategy. The obtained bimetallic PCN‐224(Zr/Ti) shows greatly enhanced photocatalytic performance for the generation of reactive oxygen species under visible light, which is responsible for the effective antibacterial activities. The PCN‐224(Zr/Ti) NPs are loaded onto lactic‐co‐glycolic acid nanofibers to prepare a wound dressing, which shows high biocompatibility and minimal cytotoxicity. The wound dressing is efficient for PDT‐based in vivo healing of the chronic wound infected by MDR bacteria. Most importantly, this work does not involve any additional antibacterial agents, which is facile, low cost, and in particular, greatly explores the potential of MOFs as a powerful nonantibiotic agent in PDT.

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805033.The rapid development of microfluidics technology has promoted new innovations in materials science, particularly by interacting with biological systems, based on precise manipulation of fluids and cells within microscale confinements. This article reviews the latest advances in microfluidics-based biomaterials and biodevices, highlighting some burgeoning areas such as functional biomaterials, cell manipulations, and flexible biodevices. These areas are interconnected not only in their basic principles, in that they all employ microfluidics to control the makeup and morphology of materials, but also unify at the ultimate goals in human healthcare. The challenges and future development trends in biological application are also presented. Microfluidics

A new, novel, rapid method to detect and direct readout of drugs in human urine has been developed using dynamic surface-enhanced Raman spectroscopy (D-SERS) with portable Raman spectrometer on gold nanorods (GNRs) and a classification algorithm called support vector machines (SVM). The high-performance GNRs can generate gigantic enhancement and the SERS signals obtained using D-SERS on it have high reproducibility. On the basis of this feature of D-SERS, we have obtained SERS spectra of urine and urine containing methamphetamine (MAMP). SVM model was built using these data for fast identified and visual results. This general method was successfully applied to the detection of 3, 4-methylenedioxy methamphetamine (MDMA) in human urine. To verify the accuracy of the model, drug addicts' urine containing MAMP were detected and identified correctly and rapidly with accuracy more than 90%. The detection results were displayed directly without analysis of their SERS spectra manually. Compared with the conventional method in lab, the method only needs a 2 μL sample volume and takes no more than 2 min on the portable Raman spectrometer. It is anticipated that this method will enable rapid, convenient detection of drugs on site for the police.

Advances in bioelectronics have great potential to address unsolvable biomedical problems in the cardiovascular system. By using poly(L-lactide-co-ε-caprolactone) (PLC) that encapsulates the liquid metal to make flexible and bio-degradable electrical circuitry, we develop an electronic blood vessel that can integrate flexible electronics with three layers of blood vessel cells, to mimic and go beyond the natural blood vessel. It can improve the endothelization process through electrical stimulation and can enable controlled gene delivery into specific part of the blood vessel via electroporation. The electronic blood vessel has excellent biocompatibility in the vascular system and shows great patency three months post-implantation in a rabbit model. The electronic blood vessel would be an ideal platform to enable diagnostics and treatments in the cardiovascular system and can greatly empower personalized medicine by creating a direct link of vascular tissue-machine interface.

Electrospinning (e-spinning) still has certain limitations in flexible practicability because its conventional setup is usually quite bulky and excessively dependent on a plug (electric supply). In this article, we report on a battery-operated e-spinning apparatus (BOEA) based on miniaturization and integration. The new device gets liberated from the conventional heavy power supply, achieves the tight integration of functional parts and can be operated by a single hand due to its small volume (10.5 × 5 × 3 cm(3)) and light weight (about 120 g). Different polymers such as polyvinylpyrrolidone (PVP), polycaprolactone (PCL), polystyrene (PS), poly(lactic acid) (PLA) and poly(vinylidene fluoride) (PVDF) were electrospun into fibers successfully, which confirms the stable performance and good real-time control capability of the apparatus. These results demonstrate that the BOEA could be potentially applied in many fields, especially in biomedical fields such as skin damage, wound healing, rapid hemostasis, etc.

Wearable and implantable devices are more versatile than traditional rigid devices. One important class of these devices is wearable sensors, which can maximize performance, minimize the risk of injury, help track movements, or serve as biomechanical and biochemical markers. Wearable devices require biocompatible and stretchable conductors with high conductivity. [1-5] Traditional materials cannot meet all these requirements. There are two ways to make flexible conductors: one is to use intrinsically Highly stretchable, conductive, biocompatible conductors, and connectors are crucial for the fabrication of flexible devices. However, it remains a problem to get highly stretchable, conductive materials with low cost on a large scale. Another problem in production is the connection between soft and rigid components. Here, a new conductive nanocomposite is reported by mixing the 11-mercaptoundecanoic acid (MUA) modified liquid metal (LM) nanoparticles with polystyrene-block-polybutadiene-block-polystyrene (SBS), which is biocompatible (in vivo and in vitro), conductive (12 000 S cm −1 of conductivity), and stretchable (800% of elongation). Apart from its good performance, this material can be produced on a large scale by using a commercial polymer product and a straightforward physical production process. MUA is used to compromise the dense "gallium oxide shell" of liquid metal nanoparticles such that the whole composite can become conductive. By using resin to modify this composite, this new conductive material can be adhesive and highly conductive, and serve as a stable and efficient connector between soft conductor and rigid component. conductive and flexible materials, such as conductive polymers, [6] the other is to add conductive materials into the flexible elastomer. [7-10] The first method is often challenging to meet the need for conductivity and flexibility. Thus, many studies have adopted the second method to realize flexible conductors. [11] However, conventional conductive fillers such as carbon, [12] gold, [13] and silver [14] based nanodots, nanorods, and nanosheets are potentially toxic, difficult to synthesize, and relatively expensive. Maintaining high flexibility, high electrical conductivity, high biological safety, and low cost simultaneously is challenging due to a trade-off among these properties. Liquid metals (LM), especially gallium (Ga) and its alloy (EGaIn: 75% gallium and 25% indium), show sufficient conductivity and fluidity, which are highly suitable for stretchable conductors. [15-17] Injecting LM into the microfluidic channel can achieve stretchable conductors. [18] However, these methods are not suitable for more complicated circuits. Sonicating LM into micro/ nanoparticles yields LM ink. [19-21] LM particles are not conductive for the gallium oxide shell on the LM particles. Some conductive composites are achieved by adding LM particles into some elastomer matrix (such as polydimethylsiloxane (PDMS), ecoflex). [22-24] To make LM-elastomer composite conductive, apply pressure and str...