Microfluidic Platforms toward Rational Material Fabrication for Biomedical Applications

Zhao, Qilong; Cui, Huanqing; Wang, Yunlong; Du, Xuemin

doi:10.1002/smll.201903798

Cited by 84 publications

(60 citation statements)

References 211 publications

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“…Including aforementioned examples, several researches demonstrated considerable performance and applications of hydrogel‐based artificial muscles . Although hydrogels have shortcomings in mechanical performance, there are several differentiated advantages and corresponding promising applications.…”

Section: Hydrogel‐based Artificial Musclesmentioning

confidence: 99%

Hydrogel‐Based Artificial Muscles: Overview and Recent Progress

Park

Kim

2020

Advanced Intelligent Systems

113

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Artificial muscles are promising as an intelligent material that can replace conventional power systems to reproduce the motion of a living organism. Among various building materials, hydrogels have great advantages as artificial muscles, such as responsiveness to a wide range of stimuli, large volume deformation, and sensitivity. However, conventional hydrogel actuators that generate only isotropic volume change in response to an external stimulus cannot be considered as artificial muscles because complex deformations are not possible. Instead, programmed complex deformations originated from a rationally designed anisotropic structure are desired in artificial muscles. Herein, recent approaches for constructing stimuli‐responsive hydrogels with an anisotropic structure, thereby enabling a directional complex motion to mimic a muscle are reviewed. First, stimuli‐responsive shape‐deforming hydrogels as a main building matrix are categorized according to stimulating external signals. The representative methods for modulating the isotropic structure of a hydrogel into various anisotropic structures, such as multilayer structure, linearly oriented structure, and patterned structure are discussed. Finally, the recent strategies to achieve muscle‐like motion of hydrogels by combining stimuli responsiveness and anisotropic structures for translation from elementary contraction and expansion to programmed deformations, such as multidirectional bending, directionally amplified deformation, and compositive programmed motion, are covered.

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Section: Hydrogel‐based Artificial Musclesmentioning

confidence: 99%

Hydrogel‐Based Artificial Muscles: Overview and Recent Progress

Park

Kim

2020

Advanced Intelligent Systems

113

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“…The PDMS elastomer kit (Sylgard 184) was purchased from Dow Corning, and Span 80 and hexane were obtained from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). The uniform PDMS microspheres were prepared using a modified mechanical emulsification method [ 50 – 52 ]. The prepolymer base elastomer and the curing agent were mixed with a weight ratio of 10 : 1 under intense stirring.…”

Section: Methodsmentioning

confidence: 99%

Self-Navigated 3D Acoustic Tweezers in Complex Media Based on Time Reversal

Yang

Li³

et al. 2021

Research

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Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media. However, the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation. In this study, we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images, thereby enabling acoustic manipulation in nontransparent media. Furthermore, we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps. We achieved 3D particle manipulation in heterogeneous media (through resin baffle and ex vivo macaque and human skulls) by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves. Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery, controlled micromachine transfer, and precise treatment.

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“…Microstructures and semiconductor devices have been fabricated using silicon and glass. [15][16][17] Microuidic devices are usually fabricated with polydimethylsiloxane (PDMS) polymer, glass, silicone, and polytetrauoroethylene in the desired shape and dimensions. [18][19][20] PDMS is the most common material used to fabricate microuidic devices because of the ease of fabrication, optical transparency, gas permeability, low chemical reactivity, and inexpensiveness.…”

Section: Microfluidicsmentioning

confidence: 99%