Vitamin D metabolism, functions and needs: from science to health claims

Battault, Sylvain; Whiting, Susan J.; Peltier, Sébastien; Sadrin, Stéphane; Gerber, G. H.; Maixent, Jean-Michel

doi:10.1007/s00394-012-0430-5

Cited by 156 publications

(127 citation statements)

References 78 publications

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“…Esta ação antiproliferativa da 1,25(OH)2D tem sido explorada como estratégia terapêutica para vários tipos de câncer 22,26 .…”

Section: Vitamina D E Câncerunclassified

“…É sabido que a 1,25(OH)D aumenta as propriedades antimicrobianas de monócitos e a capacidade fagocitária dos macrófagos 26 .…”

Section: Vitamina D E Doenças Autoimunesunclassified

“…Por inibir o sistema renina-angiotensina, a 1,25(OH)D atua na regulação da pressão arterial e pode contribuir na prevenção do infarto agudo do miocárdio e dos acidentes vasculares cerebrais 26,35 . Alguns pesquisadores observaram efeitos anti-inflamatórios da VD sobre o sistema vascular e verificaram que baixas concentrações de 25(OH)D estão associadas a uma prevalência mais elevada de fatores de risco para doença cardiovascular e infarto do miocárdio 36 .…”

Section: Vitamina D E Proteção Cardiovascularunclassified

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Vitamina D em pediatria

Almeida¹,

Nogueira‐de‐Almeida²,

Ferraz³

2018

Int J Nutrol

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A vitamina D (VD) é uma das vitaminas lipossolúveis. Suas principais fontes na natureza são a dieta e a produção endógena mediada pela exposição à luz solar. Descobertas recentes mostraram que outros órgãos, que não o rim e o fígado, são também capazes de sintetizar a VD metabolicamente ativa (calcitriol). A deficiência de vitamina D (DVD) foi descrita há quase 2.000 anos e é classicamente relacionada às doenças do sistema ósteo-muscular (em especial, raquitismo e osteomalácia). Adicionalmente nos últimos anos, a DVD tem sido associada à desordens que acometem outros sistemas do organismo, como, por exemplo, asma e diabetes. Além disso, tem sido observada uma elevação da prevalência da DVD em todo o mundo, mesmo em países com boas condições de insolação. A forma mais adequada de prevenção da DVD se dá pela suplementação vitamínica já que não há limites seguros para a exposição solar. O tratamento da DVD baseia-se, principalmente, na reposição da vitamina e está indicado nas formas sintomáticas (sintomas ósteo-musculares) da carência. A intoxicação pela VD é rara e observada em lactentes e crianças jovens que ingerem doses elevadas de VD de forma aguda. Este artigo de revisão aborda estas e outras questões a respeito da VD, com ênfase especial às particularidades relacionadas às crianças e aos adolescentes. Palavras-chave:Colecalciferol. Lactente. Vitamina D. ABSTRACTVitamin D (VD) is one of the fat-soluble vitamins. Its main sources in nature are diet and exposure to sunlight. Recent findings have shown that organs other than the kidney and liver are also able to synthesize VD metabolically active (calcitriol). Vitamin D deficiency (VDD) has been described almost 2.000 years ago and is classically related to diseases of the musculoskeletal system (especially rickets and osteomalacia). However, in recent years, VDD has been linked to disorders that affect other systems in the body, such as asthma and diabetes. In addition, an increase in the prevalence of VDD worldwide has been observed, even in countries with good insolation conditions. The most appropriate way to prevent VDD is by vitamin supplementation since there are no safe limits to sun exposure.

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“…Esta ação antiproliferativa da 1,25(OH)2D tem sido explorada como estratégia terapêutica para vários tipos de câncer 22,26 .…”

Section: Vitamina D E Câncerunclassified

“…É sabido que a 1,25(OH)D aumenta as propriedades antimicrobianas de monócitos e a capacidade fagocitária dos macrófagos 26 .…”

Section: Vitamina D E Doenças Autoimunesunclassified

Section: Vitamina D E Proteção Cardiovascularunclassified

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Vitamina D em pediatria

Almeida¹,

Nogueira‐de‐Almeida²,

Ferraz³

2018

Int J Nutrol

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“…Immune cells carry VDR and 1α-hydroxylase, which produces the active metabolite 1.25(OH)2D through local synthesis and heightens immunomodulatory properties [8]. Increasing evidence indicates that vitamin D deficiency may cause dysregulation of the innate and adaptive immune systems and promote microinflammation [22].…”

Section: Vitamin D and Immune Regulationmentioning

confidence: 99%

Pleiotropic Effects of Vitamin D in Kidney Disease

Wu¹,

Lu²

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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Vitamin D is metabolized in the liver and kidneys and then converted to the active form, 1.25-dihydroxyvitamin D [1.25(OH)2D]. Chronic kidney disease patients usually lack both 25-hydroxyvitamin D [25(OH)D] and 1.25(OH)2D due to impaired renal function and 1α-hydroxylase deficiency. Chronic kidney disease patients have a high incidence of cardiovascular and infectious morbidities. Increasing evidence indicates a relationship between vitamin D deficiency and cardiovascular and infectious mortality risks. Vitamin D may have significant biological effects beyond its traditional roles on mineral and bone metabolism. Many extrarenal cells have the capability to produce local active 1.25(OH)2D in an intracrine or paracrine fashion. Vitamin D has a significant association with nonskeletal diseases, such as immunodeficiency, metabolic syndrome, insulin resistance, diabetes, hyperlipidemia, cardiovascular disease, proteinuria, and acute kidney injury. This article aims to review and summarize the pleiotropic effects of vitamin D in patients with kidney disease, particularly the immunological, metabolic, cardiovascular, and renal effects.

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“…[2] The serum vitamin D level is determined by skin synthesis through sun exposure and/or dietary intake. [3] Access this article online The sources of vitamin D are cutaneous production and diet, only some foods naturally contain it, and few are rich in vitamin D. [4] Lifestyle and physical health factors associated with low vitamin D, such as smoking, increased body mass index, inactivity, and social withdrawal (likely resulting in decreased sunlight exposure), are all more frequent in people with psychosis. [5] There are several studies that have shown a correlation between psychosis and ethnicity, especially when dark skinned people immigrate to countries of higher latitude.…”

Section: Introductionmentioning

confidence: 99%

Differences of Serum Vitamin D Level with Antipsychotic Treatment in Schizophrenic Male Patients Between Batak and Malay

Lestari¹,

Effendy²,

Amin³

et al. 2017

IJLSSR

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ABSTRACT-Background-Vitamin D levels with schizophrenia is lower than the control due to lifestyle and physical health factors such as smoking, inactivity, and social withdrawal including decreases of sunlight exposure. Asia has the lowest average of vitamin D serum levels and Europe with lighter colored skin has higher serum levels of vitamin D. The Indonesian people were known as a nation that has a diversity of ethnic groups that exist in many areas. Each tribe has differences in living habits. Ethnic diversity, culture, religion, customs, geographical location, this is reflected in our daily lives that will affect the levels of vitamin D in patients with schizophrenic. Aims: To determine the differences of serum vitamin D levels with antipsychotic treatment in schizophrenic male patients between Batak and Malay. Methods: This study was an analytical study to recruited 60 subjects of schizophrenic male patient (30 Bataknese and 30 Malayan), aged between 15 to 55 years old, period at May-Nov 2016, the acute phase with no agitation, treatment with riperidone 4 mg. Statistical analysis was using Mann Whitney U test. Blood sample for vitamin D serum was using ELFA method. Results:The vitamin D serum levels with antipsychotic treatment in schizophrenic patient were lower in Bataknese ethnic group than Malayan ethnic group, reaching statistically (22.9±3.33 ng/ml) vs (27.9±4.19 ng/ml) p<0.001. Conclusion: There are found significant differences of serum vitamin D levels with antipsychotic treatment in schizophrenic patient between Batak and Malay.

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Vitamin D metabolism, functions and needs: from science to health claims

Abstract: Vitamin D, through food fortification and supplementation, is a promising new health strategy and thus provides opportunities for food industry and nutrition researchers to work together towards determining how to achieve this potential health benefit.

Cited by 156 publications

References 78 publications

Vitamina D em pediatria

Vitamina D em pediatria

Pleiotropic Effects of Vitamin D in Kidney Disease

Differences of Serum Vitamin D Level with Antipsychotic Treatment in Schizophrenic Male Patients Between Batak and Malay

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