Differences of Serum Vitamin D Level with Antipsychotic Treatment in Schizophrenic Male Patients Between Batak and Malay

Abstract

ABSTRACT-Background-Vitamin D levels with schizophrenia is lower than the control due to lifestyle and physical health factors such as smoking, inactivity, and social withdrawal including decreases of sunlight exposure. Asia has the lowest average of vitamin D serum levels and Europe with lighter colored skin has higher serum levels of vitamin D. The Indonesian people were known as a nation that has a diversity of ethnic groups that exist in many areas. Each tribe has differences in living habits. Ethnic diversity, culture, religion, customs, geographical location, this is reflected in our daily lives that will affect the levels of vitamin D in patients with schizophrenic. Aims: To determine the differences of serum vitamin D levels with antipsychotic treatment in schizophrenic male patients between Batak and Malay. Methods: This study was an analytical study to recruited 60 subjects of schizophrenic male patient (30 Bataknese and 30 Malayan), aged between 15 to 55 years old, period at May-Nov 2016, the acute phase with no agitation, treatment with riperidone 4 mg. Statistical analysis was using Mann Whitney U test. Blood sample for vitamin D serum was using ELFA method. Results:The vitamin D serum levels with antipsychotic treatment in schizophrenic patient were lower in Bataknese ethnic group than Malayan ethnic group, reaching statistically (22.9±3.33 ng/ml) vs (27.9±4.19 ng/ml) p<0.001. Conclusion: There are found significant differences of serum vitamin D levels with antipsychotic treatment in schizophrenic patient between Batak and Malay.

Difference of Serum BDNF Levels Between Schizophrenic Patients with Smoking in Batak Male and Controls

“…Despite low prevalence of schizophrenia, it is one of the great contributors to global burden of disease. [16] The theory that changes in the metabolism of neurotropic factors are a the pathophysiological event of schizophrenia may be related to the maldevelopment phenomenon that has been postulated for groups of psychotic disorders and supported by studies that explain changes in the level of neurotrophic factors and their receptors in schizophrenia. [3] BDNF modulates the synthesis of neurotransmitters, metabolism and neuronal activity.…”