Pleiotropic Effects of Vitamin D in Kidney Disease

Wu, Chia-Chao; Lu, Kuo‐Cheng

doi:10.5772/64517

Cited by 3 publications

(1 citation statement)

References 106 publications

(112 reference statements)

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“…The ITB of nickel-based alloys was first thoroughly studied by Fiore. [49] The main reasons are summarized as follows: 1) Intragranular precipitation; [50,51] 2) Grain boundary slip; [52,53] 3) Gas phase embrittlement; [54,55] 4) Impurity segregation; [56,57] and 5) Dynamic strain aging. [58,59] The deposited metal of nitrogen-containing nickel-based flux cored welding wire in this article is a polycrystalline alloy.…”

Section: Itb Mechanismmentioning

confidence: 99%

Study on the High Temperature Tensile Properties and Strengthening Mechanism of Nitrogen Containing Nickel‐Based Deposited Metals

Dai,

Su,

Wang

et al. 2024

Adv Eng Mater

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This article investigates the tensile properties and strengthening mechanism of nitrogen‐containing nickel‐based flux cored welding wire deposited metal from room temperature to 900 °C. The results showed that the high‐temperature strength of the deposited metal increased with the addition of Tungsten and Nitrogen. When the temperature reaches 700 °C, M23C6 carbides begin to decompose. The alloying elements dissolve back into the matrix, and the solid solution strengthening effect minimizes the plasticity of the alloy. More carbonitrides are precipitated within the crystal with temperature. During high‐temperature deformation, carbonitrides fractures at the interface with the substrate due to difficulty in coordinating deformation. Therefore, the crack source formed greatly reduces the strength of the material. In addition, the stacking faults present in the low‐temperature zone have a significant impact on the work hardening of materials. The main deformation mechanism is the unit dislocation a/2 < 110> cutting precipitation phase. It can be observed that the dislocation cutting precipitation mechanism system has transformed into a dislocation bypassing precipitation mechanism system at intermediate. Finally, the anomalous yield strength (YS) and intermediate temperature brittleness phenomenon are reasonably explained. The main deformation mechanism gradually transforms into dislocation slip and climbing with temperature.

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Section: Itb Mechanismmentioning

confidence: 99%

Study on the High Temperature Tensile Properties and Strengthening Mechanism of Nitrogen Containing Nickel‐Based Deposited Metals

Dai,

Su,

Wang

et al. 2024

Adv Eng Mater

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Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4 inhibition

Wahba

Ghareib

Abdel-Ghany

et al. 2021

Can. J. Physiol. Pharmacol.

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The current study aimed to investigate the molecular mechanisms of metformin and vitamin D3-induced nephroprotection in a MetS rat model, evaluating the capacity of vitamin D3 to potentiate metformin action. MetS was induced by 10% fructose in drinking water and 3% salt of the diet. After 6 weeks, serum lipid profile and uric acid were measured, an OGTT was performed and kidney function was investigated. MetS rats with significant weight gain, dyslipidemia, hyperuricemia and dysglycemia were treated orally with metformin (200 mg/kg), vitamin D3 (10 µg/kg) or both daily for 6 weeks. At the end of the study period, anthropometrical parameters were recorded, OGTT was reperformed, urine and blood samples were collected and tissue samples were harvested at sacrifice. MetS rats showed dramatically declined renal function, enhanced intrarenal oxidative stress and inflammation and extravagant renal histopathological damages with interstitial fibrosis. Metformin and vitamin D3 significantly reversed all the aforementioned deleterious effects in MetS rats. The study has verified the nephroprotective effects of metformin and vitamin D3 in MetS, accentuating the critical role of AMPK/SIRT1 activation and DPP-4 inhibition. Given the synergistic effects of the combination, vitamin D3 is worth being investigated as an additional therapeutic agent for preventing MetS-induced nephropathy.

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Anti-Inflammatory Benefits of Vitamin D and Its Analogues against Glomerulosclerosis and Kidney Diseases

Adamantidi,

Maris,

Altantsidou

et al. 2024

Sclerosis

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Apart from the significant progress the scientific community has made during the last few decades, inflammation-mediated kidney-related diseases like chronic and diabetic kidney diseases (CKD and DKD) and glomerulosclerosis still continue to raise mortality rates. Recently, conventional therapeutic interventions have been put aside, since natural vitamin D-derived treatment has gained attention and offered several promising outcomes. Within this article, the utilization of vitamin D and its analogues as potential treatment toward kidney-related diseases, due to their anti-inflammatory, antioxidant and anti-fibrotic activity, is outlined. Vitamin D analogues including calcitriol, paricalcitol and 22-oxacalcitriol have been previously explored for such applications, but their hidden potential has yet to be further elucidated. Several clinical trials have demonstrated that vitamin D analogues’ supplementation is correlated with inflammatory signaling and oxidative stress regulation, immunity/metabolism augmentation and subsequently, kidney diseases and healthcare-related infections’ prevention, and the results of these trials are thoroughly evaluated. The highlighted research outcomes urge further study on a plethora of vitamin D analogues with a view to fully clarify their potential as substantial anti-inflammatory constituents of renal diseases-related treatment and their health-promoting properties in many kidney-associated healthcare complications and infections.

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Pleiotropic Effects of Vitamin D in Kidney Disease

Cited by 3 publications

References 106 publications

Study on the High Temperature Tensile Properties and Strengthening Mechanism of Nitrogen Containing Nickel‐Based Deposited Metals

Study on the High Temperature Tensile Properties and Strengthening Mechanism of Nitrogen Containing Nickel‐Based Deposited Metals

Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4 inhibition

Anti-Inflammatory Benefits of Vitamin D and Its Analogues against Glomerulosclerosis and Kidney Diseases

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