Visual evoked potentials in young persons with newly diagnosed diabetes: a long‐term follow‐up

Abstract

To evaluate the presence of electrophysiological abnormalities in the visual function of young persons with diabetes, visual evoked potentials were recorded, in basal conditions and after photostress, in 30 patients with newly diagnosed insulin‐dependent diabetes mellitus. Their mean age was 17.6 years (3.6 SD), and their glycosated haemoglobin (HbA1c) was 9.4% (1.6 SD). Thirty healthy age‐ and sex‐matched individuals were evaluated as the control group. This study showed that the P100 latency was significantly delayed in patients with diabetes compared with the control group (p<0.01), while the N75 to P100 amplitude was similar in both groups. These measurements were repeated after 6 months, when all participants with diabetes had achieved good metabolic control (HbA1c 7.2% [1.5 SD]). At this second evaluation a complete normalisation of all parameters was observed. These findings suggest that early functional abnormalities of the optic nerve can be detected at onset of diabetes, and that glycaemic control reverses these abnormalities.

Visual evoked potential changes in patients with diabetes mellitus without retinopathy

“…[17][18][19] However, many studies also report no significant difference in the amplitude variations among the cases and controls. [20][21][22][23][24][25] The present study also demonstrated significantly increased mean interocular latency difference among the diabetics as compared to those in controls ( Table 4). The mean value was 2.42 ms±3.83 S.D for the study group while for the control group it was found to be 0.64 ms±0.71 S.D.…”

Neurocognitive Functioning in Children and Adolescents at the Time of Type 1 Diabetes Diagnosis: Associations With Glycemic Control 1 Year After Diagnosis

“…Neurophysiological changes at the time of diagnosis have been shown to persist under certain circumstances or for some patients. For example, Verrotti et al (36) documented delayed visual pathway nerve conduction within 1 week of diabetes diagnosis, which could account for impaired GPD performance. Mean visual response latencies normalized after 6 months of strict glycemic control, but strong correlations between latencies and A1C remained evident, suggesting impairment may persist in patients with poor glycemic control.…”

The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

“…Comi et al found that VEP is a simple and reliable method that can be used in the early detection of CNS functions in diabetic children (11). However, studies involving T1DM in childhood are more limited (12,13).…”