The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

Gürbüz, Gürkan; Edizer, Selvinaz; Ünalp, Aycan; Nalbantoğlu, Özlem; Tunç, Selma; Bağ, Özlem; Yılmaz, Ünsal; Malatyalı, Rana; Özkan, Behzat

doi:10.5812/ijp.80278

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Several studies investigated the relationship between P100 latency changes and long-term glycemic control, with conflicting evidence though [33,37,40,60,61]. Whilst correlation between P100 latency changes and long-term glycemic control (expressed as HbA1C levels or glycaemia) was reported by a few studies [33,34,60 several others did not confirm the latter association [29,35,38,59,[62][63][64][65][66].…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

Efficacy of ozone therapy on visual evoked potentials in diabetic patients

Izadi

Javanbakht

Sarafzadeh

et al. 2023

Diabetol Metab Syndr

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Background The involvement of the central nervous system is a frequent yet underestimated complication of diabetes mellitus. Visual evoked potentials (VEP) are a simple, sensitive, and noninvasive method for detecting early alterations in central optic pathways. The objective of this paralleled randomized controlled trial was to evaluate the impact of ozone therapy on visual pathways in diabetic patients. Methods Sixty patients with type 2 diabetes visiting clinics of Baqiyatallah university in Tehran (Iran) hospital were randomly assigned to two experimental groups: Group 1 (N = 30) undergoing a cycle of 20 sessions of systemic oxygen-ozone therapy in addition to standard therapy for metabolic control; Group 2 (N = 30)—serving as control—receiving only standard therapy against diabetes. The primary study endpoints were two VEP parameters; P100 wave latency and P100 amplitude at 3 months. Moreover, HbA1c levels were measured before the start of treatment and three months later as secondary study endpoint. Results All 60 patients completed the clinical trial. P100 latency significantly reduced at 3 months since baseline. No correlation was found between repeated measures of P100 wave latency and HbA1c (Pearson’s r = 0.169, p = 0.291). There was no significant difference between baseline values and repeated measures of P100 wave amplitude over time in either group. No adverse effects were recorded. Conclusions Ozone therapy improved the conduction of impulses in optic pathways of diabetic patients. The improved glycemic control following ozone therpay may not fully explain the reduction of P100 wave latency though; other mechanistic effects of ozone may be involved.

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Section: Interpretation Of Findingsmentioning

confidence: 99%

Efficacy of ozone therapy on visual evoked potentials in diabetic patients

Izadi

Javanbakht

Sarafzadeh

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

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“…All VEP transcripts were evaluated by the same pediatric neurologist using P100 latencies and amplitudes. 28 Abnormal VEP was defined as a delay or absence of the P100 wave.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Serum Advanced Glycation End Product Levels and Microvascular Complications in Children and Adolescents with Type 1 Diabetes Mellitus

Kırkgöz,

Acar,

Küme

et al. 2024

Turkish Archives of Pediatrics

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Objective: Advanced glycation end products (AGEs) are irreversible macromolecules formed by nonenzymatic reactions due to chronic hyperglycemia. The aim of this study was to assess the relationship between AGEs and the microvascular complications of children and adolescents with type 1 diabetes mellitus (T1DM). Materials and Methods: Twenty-six T1DM patients with microvascular complications and 58 complication-naive patients who were similar regarding age, sex, and pubertal status enrolled in the study. Anthropometric, biochemical, ophthalmologic, and neurologic variables were compared with serum AGEs levels by the fluorescence method. Results: There was no significant difference observed between the patients with complications and those without complications in terms of serum levels of AGEs and other biochemical parameters. However, the duration of T1DM and urine microalbumin–creatinine ratio (uACR) were significantly higher in the complication-positive group ( P < .001). Serum levels of AGEs were found to be similar when retinopathy, peripheral, and optic neuropathy were separately compared with the complication-naive group ( P > .05). However, patients with nephropathy had significantly higher serum levels of AGEs than patients without complications ( P = .023). In addition, there was a significant positive correlation between serum AGEs levels and uACR ( P = .042) but not other parameters ( P > .05). Conclusion: This study is the first to evaluate the association between serum AGEs levels and microvascular complications in children and adolescents with T1DM. Our study highlights that serum AGEs levels are significantly correlated with nephropathy but not with retinopathy and neuropathy. Further long-term studies with a larger sample size are required to establish a better relationship between diabetic complications and AGEs.

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The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

Cited by 2 publications

References 19 publications

Efficacy of ozone therapy on visual evoked potentials in diabetic patients

Efficacy of ozone therapy on visual evoked potentials in diabetic patients

Evaluation of Serum Advanced Glycation End Product Levels and Microvascular Complications in Children and Adolescents with Type 1 Diabetes Mellitus

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