Visceral Adipose Tissue Is Associated With Bone Microarchitecture in the Framingham Osteoporosis Study

Liu, Ching‐Ti; Broe, Kerry E; Zhou, Yanhua; Boyd, Steven K.; Cupples, L. Adrienne; Hannan, Marian T.; Lim, Elise; McLean, Robert R.; Samelson, Elizabeth J.; Bouxsein, Mary L.; Kiel, Douglas P.

doi:10.1002/jbmr.2931

Cited by 67 publications

(55 citation statements)

References 36 publications

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“…Some researchers have found an association of elevated serum UA with a higher BMD and greater muscle mass in a middle-aged and elderly Chinese population and it is suggested that the UA–BMD association was partly mediated by muscle mass 19. The Framingham Osteoporosis Study20 also found that higher amounts of visceral adipose tissue (VAT) are associated with greater BMD and better microstructure of the peripheral skeleton. These associations were also no longer significant after adjustment for BMI or weight, suggesting that the effects of VAT on the skeleton may not be substantial and may be independent of BMI or weight 20.…”

Section: Discussionmentioning

confidence: 99%

“…The Framingham Osteoporosis Study20 also found that higher amounts of visceral adipose tissue (VAT) are associated with greater BMD and better microstructure of the peripheral skeleton. These associations were also no longer significant after adjustment for BMI or weight, suggesting that the effects of VAT on the skeleton may not be substantial and may be independent of BMI or weight 20. We have also found positive association of UA with total fat mass and abdominal fat mass in our study, but these correlations disappeared after adjusting for confounding factors for UA.…”

Section: Discussionmentioning

confidence: 99%

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Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Xiao¹,

Chen²,

Feng³

et al. 2017

CIA

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ObjectivesWe aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age.MethodsA cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites.ResultsSerum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA.ConclusionOur results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Xiao¹,

Chen²,

Feng³

et al. 2017

CIA

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show abstract

“…In studies using CT technique, conducted in middle-aged and older adults, VAT has been associated with reduced bone mass, while SAT has been found to protect bone health (Table 1), although after correcting for body weight these effects become less apparent. Others also suggest that VAT is not associated with a detrimental effect on bone microarchitecture after adjusting for BMI or weight [65]. In addition, obese postmenopausal women and those with more VAT than normal-weight postmenopausal women have lower osteocalcin levels, a bone turnover marker associated with glucose metabolism in humans [66–68].…”

Section: Effects Of Fat and Obesity On Bone Mass And Qualitymentioning

confidence: 99%

Obesity is a concern for bone health with aging

2017

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Accumulating evidence supports a complex relationship between adiposity and osteoporosis in overweight/obese individuals, with local interactions and endocrine regulation by adipose tissue on bone metabolism and fracture risk in elderly populations. This review was conducted to summarize existing evidence to test the hypothesis that obesity is a risk factor for bone health in aging individuals. Mechanisms by which obesity adversely affects bone health are believed to be multiple, such as an alteration of bone-regulating hormones, inflammation, oxidative stress, the endocannabinoid system, that affect bone cell metabolism are discussed. In addition, evidence on the effect of fat mass and distribution on bone mass and quality is reviewed together with findings relating energy and fat intake with bone health. In summary, studies indicate that the positive effects of body weight on bone mineral density cannot counteract the detrimental effects of obesity on bone quality. However, the exact mechanism underlying bone deterioration in the obese is not clear yet and further research is required to elucidate the effect of adipose depots on bone and fracture risk in the obese population.

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“…A positive association between subcutaneous adipose tissue and bone density has been reported [9]. There are also conflicting data regarding the association between visceral AT and bone [10][11][12]. These controversial findings may result from a small sample size or different ethnicities in their studies.…”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Body Composition Relationships between Adipose Tissue Distribution and Peak Bone Mineral Density in Young Chinese Adults

Xiao

2020

BioMed Research International

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Background. The relationships between adipose tissue distribution and peak bone mineral density (BMD) in young adults are still unclear. The aim of this study was to investigate the body composition associations between fat mass (FM), lean mass (LM), regional adipose tissue distribution, and peak BMD across a cohort of young Chinese adults. Methods. Dual-energy X-ray absorptiometry (DXA) scans were performed on 786 men and 825 women aged from 20 to 40 years old to measure the markers for whole-body LM, FM, and BMD in the lumbar spine (LS), femoral neck (FN), and total hip (TH) areas. The android/gynoid FM ratio (A/G FMR) based on the DXA scans was calculated as an indicator of adipose tissue distribution. Pearson’s correlation and multivariable linear regression analyses were conducted to determine the body composition relationships between adipose tissue distribution and BMD of each skeletal site. Results. The body composition characteristics were different in young males and females: a higher body FM percentage was found in females, while males had higher LM and A/G FMR. The markers for WBLM and WBFM had significant positive correlations with BMD among the linear regression analyses in both genders, while the relationships between A/G FMR and BMD were different in males and females; significant inverse associations were showed in all skeletal sites for women (standard β ranged from -0.266 to -0.170, P<0.001 for all), but no significant relationships were found in men except for an inverse association in the LS skeletal site (standard β with -0.115, P=0.016). Conclusions. In this sample of young Chinese adults, both whole-body lean mass and fat mass had significant positive relationships with BMD in both genders. The A/G FMR, as an indicator of central adipose tissue distribution, was inversely associated with BMD, especially in females.

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Visceral Adipose Tissue Is Associated With Bone Microarchitecture in the Framingham Osteoporosis Study

Cited by 67 publications

References 36 publications

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Obesity is a concern for bone health with aging

Gender-Specific Body Composition Relationships between Adipose Tissue Distribution and Peak Bone Mineral Density in Young Chinese Adults

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