“…There are a number of distinct domains of OHRQoL measures involved in CLP children, such as appearance, speech, facial growth, and psychosocial interactions. 13 In the Leme et al 14 study, the presence of orofacial dysfunctions was associated with worse OHRQoL in otherwise healthy children, suggesting that oral and craniofacial diseases or disabilities may contribute to the compromise of vital actions (e.g., breathing, chewing, and swallowing) and muscle posture (e.g., mouth and tongue posture) and undermine the necessary requirements for social interactions, including speech, emotional communication, facial expression, and appearance. Notwithstanding, while there are existing studies evaluating the speech, muscle function, and facial asymmetry of children with CLP, 15,16,17,18 there is no prior study correlating oral functions with impacts on OHRQoL.…”