Verification of an Effective Dose Equivalent Model for Neutrons

Tanner, Jennifer E.; Piper, Roman K.; Leonowich, J.A.; Faust, L.G.

doi:10.1093/rpd/44.1-4.171

Cited by 3 publications

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“…Since the phantom consisted of only pure water, the uncertainty associated with non-tissue equivalence effects of the water phantom was defined to a maximal 10%. The specific value of uncertainty was estimated from the weighted average of the various organ volumes [ 24 , 25 ].…”

Section: Data Analysis and Resultsmentioning

confidence: 99%

Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model

Chu

Lin

Hsu

et al. 2012

Journal of Radiation Research

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This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scanning took only minutes to complete the clinical examination. For effective simulation of the cumulated effective dose for a patient undergoing examination, 150 TLDs were placed inside the water phantom for 6 days to monitor the gamma ray dose from the distributed Ga-67 citrate solution. The inserted TLDs represented internal organs, and the effective dose was calculated according to data in the ICRP-60 report. The water phantom was designed to model the body of a healthy human weighing 70 kg, and the water that was mixed with Ga-67 citrate solution was slowly replaced with fresh feed water to yield the required biological half life of the phantom. After continuously feeding in fresh water throughout the 6 days of TLD exposure, the TLDs were analyzed to determine the effective doses from the various biological half lives of the phantom. The derived effective dose of 185 MBq Ga-67 citrate solution for male/female (M/F) was 10.7/12.2, 10.7/12.0, 8.7/9.9 and 6.0/6.8 mSv, of biological half lives of 6.0, 4.5, 3.0 and 1.5 days, respectively. Although these experimental results correlated well with earlier empirical studies, they were lower than most calculated values. The cumulated uncertainty in the effective dose was 12.5–19.4%, which was acceptable in terms of both TLD counting statistic and reproducibility.

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Section: Data Analysis and Resultsmentioning

confidence: 99%

Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model

Chu

Lin

Hsu

et al. 2012

Journal of Radiation Research

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Mathematical modeling of the radiobiological effects of irradiation with stationary and pulsed neutron radiation

Filimonov¹,

Obaturov²

1998

At Energy

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To assess the effect of the dose rate on the development of radiobiological effects in cells we modeled the structural mutagenesis and reproductive loss of shallow-feeding cells exposed to pulsed radiation from a BARS-6 reactor and stationary neutron radiation in the P-2 and B-3 beams of a BR-10 reactor.To describe the radiobiological effects on cells we employed a previously proposed systems model of radiation structural mutagenesis of shallow-feeding cells under the action of heavy charged particles [ 13, 14], supplemented by equations governing the kinetics of repair processes. The choice of this model was dictated by the fact that it makes it possible to take account of the form of the ionizing radiation and the conditions of radiation action, including the dose rate.According to this model, assuming that the ceils are irradiated for a time t o with dose rate P, the kinetics of structural mutagenesis can be described by the system of equationswith the initial conditions R = A = ~, = 0 at t = 0. Here R and )~ are the number and rate of repairs of potentially lethal damage, respectively; ~1 and ~2 are the amount of potentially lethal and irreparable damage per unit dose and radiation; [3 is the rate of action of potentially lethal damage with formation of exchange aberrations; A is the number of unstable aberrations of chromosomes; q is the maximum repair rate; k = 1 -exp(-n I / n 0) / Zl (~1 + ~2); no is a parameter equal to the number of double-strand breaks of DNA that which increase the repair rate by 0.63q; n I is the average number of double-strand breaks induced by the passage of a single particle through the nucleus of a cell; and, Zl is the dose per particle [13].The system of equations (1)- (3) was used to describe structural mutagenesis under the action of the P-2 and B-3 stationary radiation beams of the BR-10 reactor, assuming that in this case the cells are irradiated only by neutrons, since in these beams the contribution of ~/-radiation to the total dose was about 5%.Since the contribution of Trays to the dose range of interest to us in the pulsed radiation of a BARS-6 reactor reaches 50%, in this case the effect of mixed T--neutron radiation must be considered. The system of equations describing the kinetics of structural mutagenesis under the action of such radiation has the form for t <_ t 0 for t > t o k = (~ (1 -k 7) + ~k 7)P -LR -[~R2; k = -~,R -[3 R2;Medical Radiological Science Center of the Russian Academy of Medical Sciences.

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Wieczorek

Pan

2000

Journal of Radioanalytical and Nuclear Chemistry

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Verification of an Effective Dose Equivalent Model for Neutrons

Cited by 3 publications

References 0 publications

Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model

Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model

Mathematical modeling of the radiobiological effects of irradiation with stationary and pulsed neutron radiation

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