Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model

Chu, Kuang Hua; Lin, Yen Ting; Hsu, Chia-Chen; Chen, Chien-Yi; Pan, Lung‐Kwang

doi:10.1093/jrr/rrs050

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…Thermoluminescent dosimeters (TLDs) have been proposed as useful tools for estimation of internal radiation Australas Phys Eng Sci Med absorbed dose [25][26][27][28] in nuclear medicine and phantom studies. A number of LiF:Mg,Ti (TLD-100) extremity dosimeters from Harshaw with the Harshaw/Bicron Model 3500 TLD reader from Thermo Electronic Corporation (USA) were used for measurement of absorbed doses in the head phantom.…”

Section: Tld Measurementmentioning

confidence: 99%

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Asl

Nasseri

Parach

et al. 2015

Australas Phys Eng Sci Med

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Monte Carlo techniques are widely employed in internal dosimetry to obtain better estimates of absorbed dose distributions from irradiation sources in medicine. Accurate 3D absorbed dosimetry would be useful for risk assessment of inducing deterministic and stochastic biological effects for both therapeutic and diagnostic radiopharmaceuticals in nuclear medicine. The goal of this study was to experimentally evaluate the use of Geant4 application for tomographic emission (GATE) Monte Carlo package for 3D internal dosimetry using the head portion of the RANDO phantom. GATE package (version 6.1) was used to create a voxel model of a human head phantom from computed tomography (CT) images. Matrix dimensions consisted of 319 × 216 × 30 voxels (0.7871 × 0.7871 × 5 mm(3)). Measurements were made using thermoluminescent dosimeters (TLD-100). One rod-shaped source with 94 MBq activity of (99m)Tc was positioned in the brain tissue of the posterior part of the human head phantom in slice number 2. The results of the simulation were compared with measured mean absorbed dose per cumulative activity (S value). Absorbed dose was also calculated for each slice of the digital model of the head phantom and dose volume histograms (DVHs) were computed to analyze the absolute and relative doses in each slice from the simulation data. The S-values calculated by GATE and TLD methods showed a significant correlation (correlation coefficient, r(2) ≥ 0.99, p < 0.05) with each other. The maximum relative percentage differences were ≤14% for most cases. DVHs demonstrated dose decrease along the direction of movement toward the lower slices of the head phantom. Based on the results obtained from GATE Monte Carlopackage it can be deduced that a complete dosimetry simulation study, from imaging to absorbed dose map calculation, is possible to execute in a single framework.

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Section: Tld Measurementmentioning

confidence: 99%

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Asl

Nasseri

Parach

et al. 2015

Australas Phys Eng Sci Med

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“…This scintigraphy is accessible in most paediatric nephrology units and it is easily obtained at a lower biological cost. By using the dose recommendations of the European Pediatric Task Group [ 13 ], the radiation dose for DMSA scintigraphy has been estimated as 1 mSv regardless of the child’s age, a burden that is significantly lower than that associated with Ga-67 scintigraphy [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of 99mTc-dimercaptosuccinic acid renal scan in the diagnosis and follow-up of acute tubulointerstitial nephritis in children

Vidal

Miorin

Zucchetta

et al. 2017

Clinical Kidney Journal

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BackgroundSymptoms and signs of acute tubulointerstitial nephritis (ATIN) are nonspecific; therefore, renal biopsy is often necessary to clarify the diagnosis. The aim of this study was to evaluate the use of 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy in the diagnosis and follow-up of ATIN.MethodsWe retrospectively reviewed the charts of five patients (nine renal units) with a median age of 14 years who underwent DMSA scan after a clinical and/or biopsy-proven diagnosis of ATIN. The exam was performed within 1 month after disease onset and repeated at a median time of 12 months after the acute phase.ResultsDMSA renal scans performed during the acute phase allowed the discovery of suggestive findings, including diffuse reduction of the renal uptake of radionuclide and presence of multiple ‘cold’ focal lesions in a corticomedullary distribution. The follow-up scintigraphy resulted normal in two patients who were treated with steroids and in one patient who presented a mild renal dysfunction in the acute phase. By contrast, the control scan showed persistent renal damage in one patient who was further readmitted because of hypertension and in one renal transplanted patient who presented a Stage 3 acute kidney injury in the acute phase.ConclusionsDMSA renal scan might be a reliable tool for an early non-invasive diagnosis of ATIN in children and might be particularly useful in those patients who are not candidates for a kidney biopsy. Moreover, DMSA scan gives accurate follow-up evaluation, as it allows monitoring of the evolution of acute renal parenchymal inflammation with potential risk of renal scar formation. Due to the small sample size, our findings warrant further validation in a larger study.

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“…[3,4,7,8] These TLDs have been shown to be accurate dosimeters for linacs operated at 6 MV. Throughout the experiment, the TLDs were always handed with great care, avoiding direct contact with dirt or hand material.…”

Section: Thermoluminescent Dosimeters (Tld)mentioning

confidence: 96%

“…Throughout the experiment, the TLDs were always handed with great care, avoiding direct contact with dirt or hand material. [3,4,7,8] …”

Section: Thermoluminescent Dosimeters (Tld)mentioning

confidence: 99%

Evaluating environment radiations at Axesse linac undergoing NPC treatment of VMAT

Chen

Tseng

Pan

et al. 2016

Computer Assisted Surgery

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Environment radiations in vault rooms resulting from Axesse linac use was assessed at Medical University Hospital using Thermoluminescent dosimeters (TLDs) during the use of the new radiation treatment known as volumetric modulated arc therapy (VMAT) in the treatment of nasopharyngeal cancer (NPC). The TLD-100H was calibrated using linac 6 MV photons. A total of 75 measurement points of the TLD-100H were utilized for environmental monitoring. The measured environment radiations were then visualized as three-dimensional graphical representations. Environment radiations were visualized using colored three-dimentional graphical representations. The radiations in NPC treatment of Rando phantom was found to reach levels up to 370 mSv/treatment. Many researchers consider TLD, which is the most cost-effective method to environment radiations. The minimum detectable dose (MDD) was also identified to demonstrate the reliability of the TLD approach. Quantitative results that provide practical guidance with regarded radiation protections. Potentially hazardous of secondary radiations from the operating linac is evaluated with regard to its potential health effects on both patients and the public. KEY POINTSThis work tried to evaluate the environment radiation and minimal detectable limit of TLD inside the LINAC maze.

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Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model

Cited by 11 publications

References 25 publications

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Usefulness of 99mTc-dimercaptosuccinic acid renal scan in the diagnosis and follow-up of acute tubulointerstitial nephritis in children

Evaluating environment radiations at Axesse linac undergoing NPC treatment of VMAT

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