2015
DOI: 10.1016/j.jprot.2015.02.012
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Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia

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Cited by 147 publications
(160 citation statements)
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“…However, geographical variations of snake venoms should not be disregarded, as ramifications have been demonstrated in the discrepancies of venom toxicity and therapeutic response to antivenom of a single geographical source. 2,18 This is particularly relevant in the case of cobra for two obvious reasons: first, cobra distributes widely in many parts of Pakistan and adapts well to human settlements, constituting a common cause of bites in the country; second, antivenom neutralization potency against cobra venom has been reported to be low, ostensibly due to the poor immunogenicity of small polypeptide toxins in the venom. 19 In view of these, this study was conducted to investigate the immunoneutralization profile of the Pakistani N. naja venom, using different cobra antivenoms available in the region.…”
Section: 12mentioning
confidence: 99%
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“…However, geographical variations of snake venoms should not be disregarded, as ramifications have been demonstrated in the discrepancies of venom toxicity and therapeutic response to antivenom of a single geographical source. 2,18 This is particularly relevant in the case of cobra for two obvious reasons: first, cobra distributes widely in many parts of Pakistan and adapts well to human settlements, constituting a common cause of bites in the country; second, antivenom neutralization potency against cobra venom has been reported to be low, ostensibly due to the poor immunogenicity of small polypeptide toxins in the venom. 19 In view of these, this study was conducted to investigate the immunoneutralization profile of the Pakistani N. naja venom, using different cobra antivenoms available in the region.…”
Section: 12mentioning
confidence: 99%
“…The exact epidemiology and the global burden measure of snakebite envenomation, however, remains elusive due to the lack of reliable information on incidence, morbidity, and mortality. 1,2 Most figures available were obtained from fragmentary surveys conducted in limited regions, representing only a small fraction of the true epidemiology. 3 Persistent underreporting of the mortality and morbidity of snakebite envenomation earned it the most neglected status among the World Health Organization listed tropical neglected diseases/conditions.…”
Section: Introductionmentioning
confidence: 99%
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“…Recent progress on the understanding of geographical variations of snake venomics at the species and intra-species levels has indeed provided useful information for this purpose [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Combined, these toxins cause a synergistic potent toxic effect leading to flaccid paralysis and respiratory failure in victims and prey. In contrast to these examples, synergistic behaviour is not observed for the neurotoxic venom of Naja kaouthia (monocled cobra), which may be due to the fact that the α-neurotoxins dominating the venom all target the same receptor (Tan et al, 2015. Instead of causing synergistic action, the α-neurotoxins compete with each other for the target, causing additive, but not synergistic effects ( Figure 2E).…”
Section: Intermolecular Synergismmentioning
confidence: 86%