2015
DOI: 10.1016/j.jprot.2015.07.015
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Cobra venom proteome and glycome determined from individual snakes of Naja atra reveal medically important dynamic range and systematic geographic variation

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Cited by 88 publications
(87 citation statements)
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References 51 publications
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“…Ironically, this was seen with NBAV, which was thought to be able to perform better on SNTX, as one of its immunogens, N. atra venom contains a higher share of SNTXs. 18 The findings are consistent with previous studies that revealed weak neutralization capacity of antivenoms toward SNTXs. 19,25 The findings also reflect the difficulty in raising immunoglobulins with sufficiently good reactivity toward SNTXs of elapid species.…”
Section: Discussionsupporting
confidence: 93%
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“…Ironically, this was seen with NBAV, which was thought to be able to perform better on SNTX, as one of its immunogens, N. atra venom contains a higher share of SNTXs. 18 The findings are consistent with previous studies that revealed weak neutralization capacity of antivenoms toward SNTXs. 19,25 The findings also reflect the difficulty in raising immunoglobulins with sufficiently good reactivity toward SNTXs of elapid species.…”
Section: Discussionsupporting
confidence: 93%
“…The Taiwanese product, NBAV, was the least effective in this study although N. atra (Taiwan) venom is known to contain a substantial amount of SNTXs (but not LNTXs). 18 This implies the possibility that antivenom produced against predominantly SNTXs would have limitation in neutralizing venom with abundant LNTXs. This was further elucidated in the neutralization study of individual toxins.…”
Section: Discussionmentioning
confidence: 99%
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“…SVMPs from T. wagleri have never been isolated and studied, therefore there is a need to study these SVMPs and elucidate their biological activity and function. It is possible that intraspecific snake venom variations and regional variations could contribute toward the presence of SVMPs in the venom [32,33]. More extensive study using samples from various regions where T. wagleri is endemic is required to confirm this possibility.…”
Section: Resultsmentioning
confidence: 99%